30 articles - From Friday Jan 06 2023 to Friday Jan 13 2023
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Arthritis Res Ther |
Potential effects of teriparatide (PTH (1-34)) on osteoarthritis: a systematic review. The SR demonstrated that PTH (1-34) could alleviate the progression of OA. Moreover, PTH (1-34) had beneficial effects on osteoporotic OA (OPOA) models, which might be a therapeutic option for OA and OPOA treatment. |
RCT, clinical trials, retrospective studies, etc…
| Ann Rheum Dis |
Influence of active versus placebo control on treatment responses in randomised controlled trials in rheumatoid arthritis. Placebo controlled trials lead to smaller effect sizes of active compounds in RCTs compared with the same compound in head-to-head trials. This difference may be explained by potential nocebo effects in placebo-controlled settings and needs to be considered when interpreting head-to-head and placebo-controlled trials, by patients, investigators, sponsors and regulatory agencies. |
Matching researchers' needs and patients' contributions: practical tips for meaningful patient engagement from the field of rheumatology. They are meant as starting points for discussion or interview. Regardless of individual qualities and knowledge, we believe that al patients engaged in research have a single goal in common: to contribute to research that ultimately will change the lives of many other patients. |
Towards development of treat to target (T2T) in childhood-onset systemic lupus erythematosus: PReS-endorsed overarching principles and points-to-consider from an international task force. These international, consensus agreed overarching principles and points-to-consider for T2T in cSLE lay the foundation for future T2T approaches in cSLE, endorsed by the Paediatric Rheumatology European Society. |
| Arthritis Care Res (Hoboken) |
Birth outcomes and re-hospitalizations among pregnant women with rheumatoid arthritis and systemic lupus erythematosus and their offspring. Women with RA or SLE and their infants experienced adverse outcomes, particularly infants of women with SLE. Maternal/infant rehospitalization was more common; most marked in the early months postpartum. Close follow-up during these time periods is crucial to minimize adverse outcomes. |
| Arthritis Res Ther |
Differential CpG DNA methylation of peripheral B cells, CD4+ T cells, and salivary gland tissues in IgG4-related disease. This is the first DNA methylation study in peripheral B cells, CD4 + T cells, and salivary gland tissues from IgG4-RD patients. Our findings highlighted the role of epigenetic modification of DNA methylation and identified several genes and pathways possibly involved in IgG4-RD pathogenesis. |
Hypertension contributes to exacerbated osteoarthritis pathophysiology in rats in a sex-dependent manner. In females, this trend held true only in OA animals (normotensive vs hypertensive p = 0.005). These data provide preliminary evidence that hypertension influences OA progression and encourages further study into the autonomic nervous system as a possible mechanism. |
Individual immune cell and cytokine profiles determine platelet-rich plasma composition. Individuals with elevated levels of cells with pro-inflammatory properties maintain these in the final PRP products. The concentration of pro-inflammatory cytokines strongly varies between PRP products. These observations may help to unravel the previously described heterogeneous response to PRP in OA therapy, especially as IFN- |
Integrative metabolomics of plasma and PBMCs identifies distinctive metabolic signatures in Behçet's disease. We identified metabolic biomarkers from plasma PBMC, which selectively discriminated BD from healthy control and patients with similar symptoms (recurrent mouth ulcers with/without genital ulcers). The strong correlation was determined between the BD activity and the lipid molecules. These findings may lead to the development for diagnostic and prognostic biomarkers based on a better understanding of the BD pathomechanism. |
| Arthritis Rheumatol |
Targeting synovial lymphatic function as a novel therapeutic intervention for age-related osteoarthritis in mice. SLS function is reduced in aged knees due to decreased VEGF-C/VEGFR3 signaling. VEGF-C treatment attenuates osteoarthritic joint damage and improves synovial lymphatic drainage in aged mice. The SLS and VEGF-C/VEGFR3 signaling represent novel physio-pathological mechanisms and therapeutic targets for age-related osteoarthritis. |
| Rheumatology (Oxford) |
A multidisciplinary lifestyle program for rheumatoid arthritis: the "Plants for Joints" randomized controlled trial. The 16-week PFJ multidisciplinary lifestyle program substantially decreased disease activity and improved metabolic status in people with RA with low-moderate disease activity. |
Epigenetic changes in inflammatory arthritis monocytes contribute to disease and can be targeted by JAK inhibition. This study provides novel insights into epigenetic regulation of inflammatory arthritis patient-derived monocytes and highlights the therapeutic potential of epigenetic modulation for the treatment of inflammatory rheumatic diseases. |
Fetal-neonatal and maternal outcomes in women with Sjögren syndrome: a population-based registry linkage study. Women with SS have significant risks of adverse fetal-neonatal and maternal outcomes and must undergo prenatal counseling to understand the risks involved before conception. |
Humoral responses against HDL are linked to lipoprotein traits, atherosclerosis, inflammation and pathogenic pathways during early arthritis stages. Humoral responses against HDL particles are an early event along arthritis course, although quantitative and qualitative differences can be noticed among stages. These differences informed distinct capacities as biomarkers and underlying pathogenic circuits. |
Neutrophil function following treatment of psoriatic arthritis patients with secukinumab: altered cytokine signalling but no impairment of host defence. Complex changes in the properties of circulating neutrophils occur with secukinumab treatment in PsA that may indicate altered responsiveness to changes in both local and systemic levels of pro-inflammatory cytokines. However, host defence processes of neutrophils were unaltered. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Ann Rheum Dis |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Ann Rheum Dis |
| Rheumatology (Oxford) |
Letters to the editors and authors’ replies
| Arthritis Rheumatol |