42 articles - From Friday Jan 06 2023 to Friday Jan 13 2023
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Nat Rev Nephrol |
Clinical practice recommendations for primary hyperoxaluria: an expert consensus statement from ERKNet and OxalEurope. In response to this need, a consensus development core group, comprising (paediatric) nephrologists, (paediatric) urologists, biochemists and geneticists from OxalEurope and the European Rare Kidney Disease Reference Network (ERKNet), formulated and graded statements relating to the management of PH on the basis of existing evidence. Consensus was reached following review of the recommendations by representatives of OxalEurope, ESPN, ERKNet and ERA, resulting in 48 practical statements relating to the diagnosis and management of PH, including consideration of conventional therapy (conservative therapy, dialysis and transplantation), new therapies and recommendations for patient follow-up. |
meta-analyses and systematic reviews
| Kidney Int |
Fluid volume management in hemodialysis: never give up! In the era of machine learning, fluid management could consist of flexible target weight prescriptions, adjusted on a daily basis and accounting even for fluctuations in fluid-free body mass. In view of al the negative prospective results surrounding fluid management in hemodialysis, we propose this as a "never-give-up" approach. |
RCT, clinical trials, retrospective studies, etc…
| Am J Kidney Dis |
Acute Kidney Injury and Hair Straightening Products: A Case Series. This study describes cases of acute kidney injury with prior exposure to hair straightening treatments. Acute oxalate nephropathy was the dominant finding on kidney biopsies, which may be related to absorption of glycolic acid derivatives and their metabolism to oxalate. This case series suggests a potential under-recognized cause of AKI in the young healthy population. Further studies are needed to confirm this association and to assess the extent of this phenomenon as well as its pathogenesis. |
Age of Onset and Disease Course in Biopsy-Proven Minimal Change Disease: An Analysis From the Cure Glomerulopathy Network. Among patients with MCD who underwent kidney biopsy, there were differences in the course (relapse and remission) of childhood-onset compared to adolescent and adult-onset disease, as well as rituximab response. |
Daratumumab Use Prior to Kidney Transplant and T-Cell-Mediated Rejection: A Case Report. To date, there are no published reports of an association with daratumumab use and T-cell mediated rejection in vivo. In this case report we present the first documented case of an early severe T-cell mediated rejection in a low immunologic risk living donor kidney transplant recipient who received daratumumab for multiple myeloma maintenance prior to transplant. |
Identification of Novel Genetic Risk Factors for Focal Segmental Glomerulosclerosis in Children: Results From the Chronic Kidney Disease in Children (CKiD) Cohort. Our genetic study has identified functionally relevant risk factors and the importance of immune regulation for pediatric primary FSGS, which contributes to a better description of its molecular pathophysiological mechanisms. |
Muscle Oxygenation and Microvascular Reactivity Across Different Stages of CKD: A Near-Infrared Spectroscopy Study. Although no differences were observed in muscle oxygenation at rest or during occlusion, the microvascular hyperemic response during reperfusion was significantly impaired in CKD and was most prominent in more advanced CKD stages. This impaired ability of microvasculature to respond to stimuli may be a crucial component of the adverse vascular profile of patients with CKD and may contribute to exercise intolerance. |
Risk Factors for Incident CKD in Black and White Americans: The REGARDS Study. Established CKD risk factors accounted for higher risk of incident CKD in Black vs White individuals. Albuminuria was a stronger risk factor for eGFR decline and incident CKD in Black compared to White individuals. Living in the US stroke belt is a novel risk factor for CKD. |
| Clin J Am Soc Nephrol |
APOL1 Risk Variants and Acute Kidney Injury in Black Americans with COVID-19. Background and objectives Black Americans have a higher incidence of kidney disease compared with populations that do not have recent African ancestry. Two risk variants in the high-risk alleles are associated with greater odds of AKI in Black American patients with COVID-19. |
Video-Based Telemedicine for Kidney Disease Care: A Scoping Review. Video-based telemedicine is being used for kidney care and has evolved to be less reliant on specialized telemedicine equipment. As its use continues to grow, further primary studies and systematic reviews of outcomes associated with the latest innovations to video-based care in nephrology can address knowledge gaps, such as approaches to sustainable integration and minimization of barriers to access. |
| Kidney Int |
A beautiful, complex simplicity: the origins of nephron segmentation uncovered by single-cell sequencing of the pronephros. As mammalian kidneys evolved from the simple pronephric kidneys of the early vertebrates, understanding the structure and function of pronephroi gives insight into the blueprints underlying al nephrons. The article in this issue by Corkins et al uses single-cell sequencing to demonstrate an extraordinary segmental complexity and the organizational roadmap that mammalian nephrons are based upon. |
Finerenone in chronic kidney disease and type 2 diabetes: the known and the unknown. In this issue of Kidney International, Bakris et al present new data on the kidney efficacy of finerenone across subgroups of estimated glomerular filtration rate and urinary albumin-to-creatinine ratio, as well as safety data. We attempt to place these results in context by discussing the benefits and risks of finerenone, as well as the generalizability of the study findings to routine care settings. |
Inadvertent stem cell transfer demonstrating a way for tolerance induction. This report not only highlights the chimerism approach for tolerance induction in transplantation, but it is also the first evidence of hematopoietic stem cells in human kidneys. This commentary discusses the potency and risks of the chimerism approach for tolerance induction after solid organ transplantation, especially in (pediatric) patients with immune deficiencies. |
Transcriptional programming of pathogenic genes in polycystic kidney disease. Lakhia et al identified an enhancer landscape associated with disease genes and its pathologic role in autosomal dominant polycystic kidney disease to understand cyst formation. This commentary discusses these findings reported by Lakhia et al in the broader contexts of transcriptional programming and the identification of potential autosomal dominant polycystic kidney disease therapeutic targets. |
Youth with single kidneys-what is the evidence of risk? The risk of progressive kidney disease for those with a single functioning kidney varies, and how to assess it remains imperfect. Developing better measures to determine the risk of chronic kidney disease-renal functional reserve and imaging that includes nephron number-may be within reach and would likely positively affect the outcome. |
| Nephrol Dial Transplant |
Factors influencing kidney transplantation rates: a study from the ERA Registry. In particular in low KT rate countries, KT rate might be stimulated by optimizing staff, equipment, and facilities. In addition, al countries may benefit from deceased and living donor specific measures. |
Long-term outcomes and prognostic factors for survival of patients with ANCA-associated vasculitis. Patients with AAV still have an increased risk of mortality compared to the general population despite newer therapeutic regimens. Treatment complications and organ damage are the main causes of limited survival, and infections remain the leading cause of mortality among patients with AAV. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Am J Kidney Dis |
Nutritional Epidemiology and Dietary Assessment for Patients With Kidney Disease: A Primer. Novel approaches that assess diet more objectively are gaining popularity but have not yet fully replaced self-report and require refinement and validation in populations with chronic kidney disease. More accurate and frequent diet assessment in existing and future studies will yield evidence to better personalize dietary recommendations for the prevention and treatment of kidney disease. |
| Clin J Am Soc Nephrol |
| J Am Soc Nephrol |
| Kidney Int |
| Nat Rev Nephrol |
Regulation of FGF23 production and phosphate metabolism by bone-kidney interactions. Understanding of the molecular mechanisms that control FGF23 synthesis in the bone and its bioactivity in the kidney has led to the identification of potential targets for novel interventions. Emerging approaches to target aberrant phosphate metabolism include small molecule inhibitors that directly bind FGF23 and prevent its interactions with FGF receptors and a-Klotho, FGF23 peptide fragments that act as competitive inhibitors of intact FGF23 and small molecule inhibitors of kidney sodium-phosphate cotransporters. |
The gut microbiome and hypertension. Several methodological and technological challenges remain in gut microbiome research, and the solutions involve minimizing confounding factors, establishing causality and acting globally to improve sample diversity. New clinical trials, precision microbiome medicine and computational methods such as Mendelian randomization have the potential to enable leveraging of the microbiome for translational applications to lower blood pressure. |
The role of immune cells and mediators in preeclampsia. Immunological interventions, therefore, have therapeutic potential in this disease. Here, we provide an overview of the immune responses that are involved in the pathogenesis of preeclampsia, including the role of innate and adaptive immune cells and mediators. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Clin J Am Soc Nephrol |
| J Am Soc Nephrol |
| Kidney Int |
Letters to the editors and authors’ replies
| J Am Soc Nephrol |
| Kidney Int |