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50 articles - From Friday Jun 06 2025 to Friday Jun 13 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Inflamm Bowel Dis |
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The Association of Inflammatory Bowel Disease and Eosinophilic Esophagitis: A Systematic Review and Meta-analysis. Both IBD and atopic dermatitis were associated with an increased odds of EoE diagnosis. Further research is needed to determine the underlying mechanisms behind these potential associations. |
| J Crohns Colitis |
Gene-Environment Interactions in Inflammatory Bowel Disease: A Systematic Review of Human Epidemiologic Studies. Current evidence indicated that the IBD risk conferred by environmental factors can vary among the individuals carrying certain genetic variants. Further efforts, including genome wide environment interaction studies and genotype-based nutrition/lifestyle clinical trials, are needed to unravel the missing heritability influenced by environmental exposures and to construct personalized recommendations of lifestyle/dietary modification based on an individual genetic background. |
| Pancreatology |
Association between ABO blood groups and pancreatic cancer outcomes: A systematic review and meta-analysis. Patients with blood type O exhibited better OS and were less frequently diagnosed with advanced cancer stages (III-IV) upon presentation compared to those with non-O blood types. Further research is needed to investigate the mechanisms underlying these associations. |
RCT, clinical trials, retrospective studies, etc…
| Am J Clin Nutr |
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Adherence to plant-based diets and long-term changes in cardiometabolic markers: a longitudinal analysis in a population-based cohort. Greater adherence to more plant-based dietary patterns, particularly those rich in healthy plant-based foods, is associated with favorable long-term changes in early cardiometabolic markers. Our findings provide further support for recommendations to transition to more healthy plant-based diets for early prevention of cardiometabolic risk. |
Assessment of immune function in individuals without and with obesity and normoglycemia, glucose intolerance, or type 2 diabetes: primary findings of the NutrIMM study, a single-arm controlled feeding trial. Immune function is compromised in obesity and worsens in T2D, suggesting both obesity and poor glucose control drive immune dysfunction. Addressing metabolic health may help mitigate immune dysfunction and inflammation in obesity-related conditions. |
Biomarkers of environmental enteric dysfunction and neurodevelopmental outcomes among children in rural Bangladesh and Kenya: a prospective cohort study. Higher concentrations of biomarkers of intestinal permeability were associated with poor child motor development in Bangladesh. These relationships were not replicated in the Kenyan cohort. The associations between EED and child neurodevelopment vary across geographical contexts, highlighting the need for further research to determine the generalizability of these findings. |
Can nutrition-sensitive agriculture interventions address intersectional inequalities in women's diets? A mediation analysis using cross-sectional trial data from Odisha, India. To our knowledge, this is the first intersectionality-informed analysis of nutrition interventions. UPAVAN interventions mostly has equitable impacts, reducing several inequalities in maternal diet quality. We demonstrate how intersectionality-informed analyses can help identify inequities in nutrition interventions and inform the design of inclusive interventions that reach and benefit the most marginalized groups. |
Duration and intensity of lactation and maternal risk of subsequent incident coronary artery disease and stroke-a prospective cohort study. Limited evidence exists for an association between lactation and maternal risk of stroke. Longer durations of lactation are associated with lower risks of maternal CAD diagnosed before age 70 y. Adjustment for risk factors attenuate the associations, which suggests these factors may partly confound the benefits of lactation on maternal risks of CAD. |
Effects of a palmitoleic acid concentrated oil on C-reactive protein levels in adults: A randomized, double-blind placebo-controlled clinical trial. Compared to placebo, supplementation for 12 wk with 500 mg/d or 1000 mg/d POA did not significantly lower hs-CRP or change other biomarkers. |
Longitudinal Associations Between Vegetarian Dietary Habits and Site-Specific Cancers in the Adventist Health Study-2 North American cohort. These data indicate lower risk in vegetarians for al cancers combined, also for medium frequency cancers as a group. Specific cancers with evidence of lower risk, are breast, colorectal, prostate, stomach, and lymphoproliferative subtypes. Risk at some other sites may also differ in vegetarians, but statistical power was limited. |
Metabolic profile of biodiverse diets in a healthy European cohort. In this European middle-aged adult population, the circulating metabolic profiles of biodiverse diets are consistent with the metabolome linked with health-promoting diets, indicating metabolite groups that provide metabolic homeostasis, anti-inflammatory, anti-oxidative stress, and anti-obesogenic properties. These findings support the health benefits of consuming more diverse dietary species and may partially explain the inverse associations found in relation with mortality or gastrointestinal cancer. |
Mortality burden of protein-energy malnutrition associated with ambient temperature in China:a nationwide case-crossover study. Findings from this nationwide study suggest that both heat and cold are associated with increased risks and burden of PEM-related deaths. These findings underscore the necessity of targeted interventions to reduce the PEM-related mortality burden associated with ambient temperature. |
Nutritional priorities to support GLP-1 therapy for obesity: a joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society. Evidence-based nutritional and lifestyle strategies play a pivotal role to address key challenges around GLP-1 treatment of obesity, making clinicians more effective in advancing their patients' health. |
One-carbon metabolism-related compounds are associated with epigenetic aging biomarkers: results from the cross-sectional National Health and Nutrition Examination Survey 1999-2002. In a nationally representative sample of United States adults, higher concentration of folate, a carbon donor, was associated with lower EAD, and higher concentration of Hcys, an indicator of OCM deficiencies, was associated with greater EAD; however, some associations were influenced by smoking and renal function. Future research should focus on high-risk populations. Long-term randomized controlled trials are also needed to establish causality and investigate the clinical relevance of changes in EAD. |
Paving the way for improved action: how nuclear techniques can advance the assessment of malnutrition. The integration of nuclear techniques with emerging tools such as artificial intelligence and model-based compartmental analysis was emphasized as a key strategy to enhance their utility. This report also highlights the important role of nuclear techniques in addressing malnutrition and calls for interdisciplinary collaboration and reduced research silos to fully leverage these techniques to combat this condition more effectively. |
Short-Term High Fat Diet Induced Metabolic Endotoxemia in Older Individuals with Obesity: A Randomized Crossover Study. Serum endotoxin concentrations in individuals with obesity increase following a HF diet or meal and these data suggest it is explained by intestinal permeability rather than a shift in the gut microbiome. Clinical trial registration |
The potential of nighttime urine samples for epidemiologic research on sodium intake: Evidence from a population-based cohort study in Switzerland. Estimating 24-h UNa excretion based on nighttime collections was found to be imprecise and/or biased at the individual level and failed to capture population-level characteristics beyond central tendency. |
Ultra-processed foods, plant and animal sources, and all-cause, cardiovascular, and cancer mortality in older adults in the United States: results from the Cardiovascular Health Study. Higher consumption of UPF and plant- and animal-sourced UPFs was associated with higher risk of all-cause, non-CVD-related, and cancer mortality. Our findings emphasize the need to consider the impact of food processing, even in plant-sourced foods, to prevent a shorter lifespan in older adults. Findings on plant-sourced UPF and mortality require replication. |
| J Crohns Colitis |
Achievement of long-term treatment goals in upadacitinib-treated patients with moderately to severely active ulcerative colitis: a post hoc analysis of phase 3 trial data. Upadacitinib may help patients with moderately to severely active UC achieve complete symptom resolution, endoscopic remission, and normalization of HRQoL. |
Association between Food Diversity in the Infant Period and the Risk of Inflammatory Bowel Disease: A Nationwide Cohort Study in South Korea. Food diversity, combined with frequency of solid food intake, during infancy is associated with the incidence of ulcerative colitis. Promoting a diverse diet during infancy may be important in preventing the development of IBD. |
Cancer Incidence in Patients with Ulcerative Colitis Naïve to or Treated with Thiopurine and Targeted Therapies- a cohort study 2007 to 2022 with comparison to the general population. Elevated cancer incidence was observed in patients with UC amounting to around 3 extra cases of cancer per 1000 years. Cancer risks varied more among groups defined by age than by treatment. |
Impact Of Immunomodulating Medication On Maternal Tdap Vaccination Induced Antibodies In Infants. Maternal Tdap vaccination in women with IBD receiving immunomodulating medication during pregnancy results in significantly higher Tdap-antibody concentrations in their infants compared to infants of unvaccinated IBD mothers, although GMC was lower for PRN compared to healthy controls. These results support current recommendations to advise maternal Tdap vaccination in pregnant women receiving immunomodulating medication. |
Impact of Mirikizumab Treatment on Fatigue in Patients with Moderately to Severely Active Crohn's Disease: Results from the Phase 3 VIVID-1 Study. Mirikizumab-treated patients with Crohn's disease achieved higher rates of clinically meaningful improvement in fatigue versus placebo at Weeks 12 and 52, which correlated with improvement in clinical and patient-reported outcomes. Baseline fatigue severity was strongly associated with depressive symptoms in VIVID-1 (NCT03926130). |
Long-term disease course of ulcerative colitis in a prospective European population-based inception cohort - an Epi-IBD cohort study. While the introduction of advanced therapies for UC has transformed the therapeutic landscape, their impact on colectomy rates, disease progression, and hospitalisations remains modest. Our findings highlight the need for continued innovation in UC treatment and the importance of individualised and targeted care to achieve optimal long-term outcomes. |
Metabolism and Response to Stress Gene Signatures Reveal Ulcerative Colitis Heterogeneity and Identify Patients With Increased Response to Therapy. We identified and evaluated a novel, multi-dimensional signature gene set to characterise previously undefined heterogeneity in patients with UC and identify patients less likely to respond to therapy. This approach offers potential utility to define clinical trial populations, enrich for clinical responders, and identify difficult-to-treat populations for therapeutic development. |
Pharmacological inhibitors of the gamma-secretase enzyme complex disrupt epithelial cell function triggering colitis in mice. In conclusion, systemic use of γ-secretase inhibitors disrupts epithelial cell function by impairing IEC differentiation and triggering gut inflammation in mice. These findings should be considered when designing future therapeutic interventions involving γ-secretase inhibitors. |
ST6GAL1 promotes IBD B cell recruitment to the inflamed colon in a CD22-dependent mechanism. Our findings suggest that endothelial ST6GAL1 creates a pro-adhesive microenvironment rich in α2,6-sialic acids that engage CD22 on circulating B cells and plasmablasts to promote their recruitment into the inflamed gut mucosa. This pathway might be a novel target to interfere with B lineage cell homing and local auto-antibody production. |
The Effectiveness of second-and-third line biologics in perianal Crohn's disease - a multicenter propensity score-matched study. In pCD patients failing anti-TNFs as 1st-line treatment, ustekinumab may be more effective than vedolizumab or another anti-TNFs as 2nd or 3rd-line therapy. |
| Liver Transpl |
Abdominal aortic calcification on routine pre-operative computed tomography - a novel cardiovascular risk prediction tool in liver transplant patients. High AAC on routine CT scans was associated with a 3-fold increased risk of 30-day MACE post-LT and improved cardiovascular risk prediction compared to traditional indices. Quantification of AAC may offer a simple method of improving cardiovascular risk assessment in these patients. |
Access to early liver transplantation is adversely impacted by social determinants of health: A retrospective cohort study. High SVI census tracts were less likely to have individuals referred for ALD compared to tracts with low SVI (IRR 0.53, 95% CI 0.42-0.66). Both individual- and neighborhood-level SDoH are important factors that ultimately influence who is eligible for transplant. |
Balancing abstinence and harm reduction across the continuum of care for liver transplantation in alcohol-associated liver disease. Based on clinical evidence, we highlight the need to examine current LT selection processes, coordinate alcohol use disorder treatment for patients with ALD, and develop comprehensive markers of post-transplant success. Finally, we discuss potential challenges and considerations when applying the harm reduction approach to nuanced scenarios of LT candidates and recipients with ALD. |
Hepatic hypoxia in donation after circulatory death: Physiology, clinical relevance, & future directions. Lastly, we touch on emerging technologies such as machine perfusion. We hope that our review unites concepts of hepatic physiology with DCD practice and enlightens readers to envision novel areas of study in this field. |
Management of obesity in liver transplant candidates & recipients: Rethinking the false dichotomy between pharmacotherapy and surgical intervention. Experts in the field presented the available data and smaller working groups had interactive breakout sessions that identified knowledge gaps and developed recommendations. This perspective prepared on behalf the participants of the AST Controversies Conference on obesity and liver transplant aims to summarize the available evidence for surgical and pharmaceutical treatment in the liver transplantation population. |
Peri- and postoperative analgesic strategies in live donor hepatectomy: A national survey. We observed a significant variation in peri- and postoperative pain management strategies after live donor hepatectomy between centers. Some centers adapt analgesic techniques based on the surgical technique (e.g., open vs laparoscopic/robotic, and right vs left lobe hepatectomy). |
Renal replacement therapy in liver transplant ineligible patients. Emerging literature suggests that the etiology of kidney injury should play less of a role in clinical decision making. Decisions around RRT are often influenced by medical, ethical, and end-of life factors and should be made in conjunction with patients and their caregivers. |
Robotic liver transplantation: University of modena experience. The robotic approach to liver transplantation has demonstrated feasibility and promising short-term outcomes. However, extended follow-up is required to confirm these results over the long term with the aim to confirm outcomes comparable to benchmark results of open transplantation. |
Steatotic liver disease after paediatric liver transplantation. Therefore, steatotic liver disease is a noteworthy histological feature during the follow-up of paediatric liver transplant recipients, yet it had a low burden on the health of the patients in this cohort. However, it needs to be monitored in the context of the increasing prevalence of metabolic syndrome. |
| Pancreatology |
Pancreatic parenchymal volume measurement for predicting invasive intraductal papillary mucinous neoplasm. Quantifying PV, particularly when combined with HRS, may improve diagnostic accuracy for invasive IPMN. Furthermore, changes in PV observed during surveillance may provide additional insight into the risk of progression to invasive IPMN. |
Perilesional branch duct dilation as a hallmark MRCP feature for differentiating high-grade PanIN from low-grade PanIN. Perilesional BPD dilation on MRCP is a primary imaging feature for differentiating HG-PanIN, characterized by substantial interobserver agreement. While PPA on MRI is another important independent predictor, its lower interobserver agreement warrants caution. These findings highlight the diagnostic value of utilizing both MRCP and MRI in the noninvasive evaluation of suspected PanIN. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Am J Clin Nutr |
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| J Crohns Colitis |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Inflamm Bowel Dis |
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| Pancreatology |
Letters to the editors and authors’ replies
| Am J Clin Nutr |
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