28 articles - From Friday May 22 2026 to Friday May 29 2026
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| J Crohns Colitis |
|---|
| Does inflammatory bowel disease play a role in cognitive decline? A systematic review.
IBD is associated with CI and increased dementia risk, with biologics potentially mitigating neuroinflammation-related decline. More longitudinal studies and randomized clinical trials, also on intermediate endpoints, are needed to clarify the neuroprotective role of some therapies and optimize treatment strategies. |
| Intestinal cancer risk in Crohn's disease: reporting, eligibility, and inference considerations in a meta-analysis. |
| TL1A as a therapeutic renaissance in inflammatory bowel disease: a systematic review from molecular mechanisms to clinical translation.
TL1A inhibitors represent a promising novel therapeutic class with dual anti-inflammatory and anti-fibrotic properties, addressing critical unmet clinical needs in IBD. These agents hold the potential to become cornerstone therapies in the evolving landscape of precision medicine for IBD care. |
RCT, clinical trials, retrospective studies, etc…
| Am J Clin Nutr |
|---|
| Best (but oft forgotten) practices: Applying the target trial framework in nutrition research.
Protocol components, including eligibility criteria, treatment strategies and assignment procedure, outcome and follow-up, causal contrast and statistical analysis plan, are clearly specified and subsequently implemented using available observational data. In this article, we explain the target trial framework approach, describe examples from nutrition research, demonstrate the practical steps of performing a target trial study, and discuss the methodological challenges and opportunities of applying the framework to nutrition research. |
| Individual glycemic responses scale predictably with the glycemic index: evidence against person-specific food effects.
In healthy adults under standardized conditions, inter-individual variation in glycemic responses is predominantly accounted for by variability in day-to-day glucose tolerance, propagating through the GI ratio. The GI concept performs within the reproducibility limits of input data. |
| Inflamm Bowel Dis |
| Impact of advanced therapy initiation on antibiotic dependence in chronic pouchitis.
Just over half of patients on AT for chronic pouchitis saw reduced antibiotic use; however, further studies are needed to identify impact of AT on antibiotic use and define which patients benefit from immune-mediated vs microbiome-directed therapy. |
| Matrix metalloproteinases in intestinal fibrosis and fibrostenosing Crohn's disease: Current evidence, mechanistic hypotheses, and translational challenges.
Candidate biomarkers and emerging therapeutic strategies remain investigational, and no MMP-directed approach has yet demonstrated clinical utility for routine fibrosis staging or stricture prevention. Future research directions should prioritize longitudinal human studies, mechanistic elucidation of how MMPs influence fibrosis and/or smooth muscle hyperplasia, improved linkage between tissue biology and imaging, fibrosis-specific endpoints, and rigorous validation before clinical trial translation can be justified. |
| Transperineal contrast-enhanced ultrasound: a rapid and reliable tool for differentiating abscesses from inflammatory masses in perianal Crohn's disease.
Transperineal CEUS significantly improves inter- and intra-observer agreement and diagnostic confidence compared with conventional B-mode TPUS when differentiating perianal abscesses from inflammatory masses/phlegmons in CD and frequently leads to lesion reclassification in clinically ambiguous cases. |
| J Crohns Colitis |
| Magnetic resonance imaging-based simplified MaRIA scores are associated with future surgery in Crohn's disease, but modest correlation with ileo-colonoscopic inflammation limits their utility in clinical trials: results from the PROFILE trial.
MRI should be considered as complementary to ileo-colonoscopy for assessing ileal Crohn's disease. sMaRIA should not replace SES-CD in clinical trials. |
| Liver Transpl |
| A HDL-based cirrhosis risk score improves the prediction of short-term mortality in acutely decompensated cirrhosis.
The new prognostic CLIF-C HDL score yields superior accuracy for prediction of short-term mortality in AD cirrhosis as compared to other prognostic scores. |
| Emerging applications of traditional and generative artificial intelligence in Liver Transplantation.
Future opportunities lie in incorporating underutilized data domains, such as psychosocial factors, -omics, and intraoperative physiologic streams, and leveraging GenAI to enhance clinical decision support, research scalability, and patient-clinician communication. AI is poised not only to refine prediction, but to reshape the conceptual and operational landscape of liver transplantation. |
| Frailty 1 year after liver transplant is associated with long-term mortality: From the Functional Assessment in Liver Transplantation (FrAILT) Study.
Patients who transitioned from not frail pre-LT to frail 1y post-LT had a 2.5-fold increased risk of post-LT mortality (95%CI 1.3-4.8, p=0.005) compared to patients who remained not frail. These findings suggest the 1y period after LT may be a critical window for evaluating whether targeted frailty-mitigation strategies may improving long-term survival among LT recipients. |
| The liver frailty index improves mortality risk prediction for GEMA-Na.
While GEMA-Na reduces gender disparities related to renal dysfunction, the added prognostic value of frailty highlights muscle health as an independent and actionable determinant of outcomes. These findings support routine frailty assessment to better stratify risk and to potentially guide timely interventions such as prehabilitation or expedited LT. |
| Pancreas |
| Clinical Variables Associated With Islet Yield and Long-Term Metabolic Outcomes following Total Pancreatectomy With Islet Autotransplantation.
Islet yield is a key determinant of long-term metabolic outcomes following TPIAT. Although the primary indication for surgery remains pain relief, patient factors including age, BMI, prior pancreatic surgery, and duration of symptoms influence islet yield and can help inform expectations for postoperative glycaemic outcomes. Notably, shorter symptom duration was associated with higher islet yield, supporting timely evaluation and referral for TPIAT before further pancreatic interventions that may compromise islet recovery. |
| Comparative Analysis of Outcomes and Readmissions Trends in Adult and Pediatric Acute Biliary Pancreatitis: A Nationwide Analysis.
Despite higher comorbidities in adults, ABP-specific local and systemic complications and mortality were similar between adults and pediatric patients. Same-admission cholecystectomy (CCY) was associated with a significant reduction in 30-day readmissions in both groups, highlighting its importance as a key intervention across age groups in acute biliary pancreatitis (ABP) cases. |
| Efficacy and Safety of Celiac Plexus Block in Chronic Pancreatitis: A Multicenter Cohort Study.
While CPB appears to reduce hospital encounters, opioid use increased over long-term follow-up, suggesting that its analgesic effect is short-lived. A randomized controlled trial is underway to determine the true efficacy of CPB in CP. |
| Emodin Alleviates Microcirculation Disorders in Acute Lung Injury Associated with Severe Acute Pancreatitis by Inhibiting Ferroptosis of Vascular Endothelial Cells.
Furthermore, Emodin upregulate the expression of GPX4 and SLC7A11, mitigate mitochondrial damage, and downregulate the expression of NCOA4 in HUVECs. Emodin inhibit ferroptosis in HUVECs by attenuating NCOA4-mediated iron autophagy, thereby ameliorating pulmonary microcirculation disorders in SAP-ALI rats. |
| Heart Rate Variability as a Tell-tale Marker of Pain-related Autonomic Dysfunction in Chronic Pancreatitis.
Chronic pancreatitis, particularly when painful, is associated with significant autonomic dysregulation, characterized by a pronounced reduction in parasympathetic activity as measured by HRV compared to pain-free patients. |
| INSPPIRE: Advances in the Understanding of Pediatric Pancreatitis.
Twenty-six sites have enrolled >1000 subjects into the INSPPIRE-2 database with available prospective data to evaluate disease progression, phenotypes, complications and outcomes. The available resources are outlined along with key discoveries offering readers topic specific information about INSPPIRE's progress. |
| Pancreatology |
| Cigarette smoking drives earlier development of pancreatic adenocarcinoma among carriers of hereditary pancreatic cancer susceptibility genes.
Cigarette smoking is associated with earlier development of PDAC among PV carriers, but smoking cessation of 10 years or more mitigates this effect. If confirmed in larger studies, these findings suggest smoking history should factor into the age at which PDAC surveillance begins. |
| Pancreatic cyst epidemiology defined by endoscopic ultrasound: A single-center longitudinal study.
PCLs are a population health problem. Mucinous phenotypes and UCs represent most PCLs and are found in older patients. EUS has a low threshold for cyst recognition (< 2 mm) and highlights UCs as a potential precursor to IPMN-BD. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Inflamm Bowel Dis |
|---|
| Response to "Epidemiology of IBD in Malaysia: a rare longitudinal lens in Asia". |
| J Crohns Colitis |
| Epigenetic biomarkers in inflammatory bowel diseases-computational challenges and opportunities.
We then discuss how recent advances in computational methodology-spanning data harmonization, integrative modeling, and interpretable machine learning-can help bridge the gap between complex datasets and reliable, deployable biomarkers. Finally, we propose a forward-looking roadmap for study design and validation aimed at moving the field toward routine clinical implementation, thereby realizing the full potential of epigenetics in IBD. |
| Pancreatology |
| Towards early detection of pancreatic cancer: The current status of cohort studies by the Diabetes-Pancreatic Ductal AdenoCarcinoma Working Group.
There are also ongoing studies on the "science of NOD" to understand its pathogenesis. Overall, the DM-PDAC Working Group has been successful in its mission to further our understanding of the link between diabetes pancreatic cancer. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| J Crohns Colitis |
|---|
| Mucocutaneous Crohn's disease without gastrointestinal symptoms: a case of oral lesions responsive to risankizumab. |
| Liver Transpl |
| Letter to the editor: Silent graft injury after pediatric liver transplantation: Beyond Protocol Biopsy? |
| Reply: Silent graft injury after pediatric Liver Transplantation: Beyond protocol biopsy? |
| Success is not final, failure is not fatal, it is the courage to continue (improving) that counts. |
Letters to the editors and authors’ replies