45 articles - From Friday Apr 10 2026 to Friday Apr 17 2026
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Am J Clin Nutr |
|---|
| Should the Dietary Guidelines for Americans include sustainability? A critical perspective.
And, the DGA has far-reaching implications for non-dietary policy, which have not been fully considered yet. Until we, as nutrition professionals, can have productive conversations about the nuances related to science, messaging, and policy, a push to include sustainability in the DGA will be counterproductive. |
meta-analyses and systematic reviews
| Am J Clin Nutr |
|---|
| Glycemic and Cardiometabolic Effects of Rare Sugars Allulose and Tagatose: A Systematic Review and Meta-Analysis of Controlled Human Intervention Trials.
Supplementation of allulose or tagatose attenuates postprandial glycemic and insulin responses, albeit with no improvements in blood lipids and body composition. Prospero identifier CRD42024567433; |
| Inflamm Bowel Dis |
| Early immunomodulator therapy reduces the risk of intestinal resection in Crohns disease: a systematic review and meta-analysis.
Early IM therapy is associated with a substantially lower risk of intestinal resection in CD compared with later or no IM therapy. The most consistent benefit occurs when treatment is initiated within the first 1-2 years after diagnosis, supporting the concept of a therapeutic "window of opportunity" during which timely IM initiation may favorably alter the disease course. |
| J Crohns Colitis |
| The predictive value of intestinal ultrasound for treatment response in inflammatory bowel disease: a systematic review and pooled data analysis.
Intestinal ultrasound predicts response at an early stage after treatment initiation, both in CD as well as in UC. In anti-TNF-treated CD patients, 23% and 27% decrease in BWT after 4-8 weeks and 12-16 weeks of treatment initiation predicts outcomes. |
RCT, clinical trials, retrospective studies, etc…
| Am J Clin Nutr |
|---|
| Associations Between Extreme Temperature Events and Daily Step Counts by Weight Status and Modifying Effects of Socio-Demographic Factors: A Longitudinal Study.
These findings suggest that individuals with low-income or high BMI are associated with heightened vulnerability to heatwaves, whereas individuals with low-income or normal BMI are linked to greater sensitivity during cold spells. |
| Determining the half-life and turnover rate of EPA, n-3 DPA, and DHA in humans using the natural abundance of carbon-13: A secondary analysis of a randomized clinical trial.
This is the first study to investigate n-3 PUFA half-lives and turnover in humans using GC-IRMS and the natural variance of 13 C in commercial fish oils. These results were similar to preclinical model values and other clinically used methods but adds the first estimate for n-3 DPA half-life and turnover. Compound specific isotope analysis (CSIA) is a valuable tool in human studies for determining n-3 PUFA half-lives and turnover, and factors affecting them including diet, exercise, sex, genetics, and disease. |
| Dietary Macronutrient Substitutions and Cardiometabolic Outcomes in Children With and Without Gestational Diabetes Exposure: A Cross-Sectional Analysis.
These findings reveal exposure-specific differences in how macronutrient composition influences cardiometabolic outcomes and highlight distinct intervention targets for children exposed and unexposed to GDM. |
| Intention-to-Treat Estimates of Prenatal Ramadan Exposure on Child Height-for-Age in the Demographic and Health Surveys.
Restricting samples to multifaith regions and accounting for growth faltering resolves conflicting findings, yielding a robust negative effect of 0.14-0.16 z-score points by age 4. Further research is needed to disentangle the specific pathways, including fasting, dietary changes, hydration, and sleep disruption, through which Ramadan exposure affects fetal development, in order to inform targeted public health guidance. Clinical Trial Registry number and website where it was obtained. Not applicable Registry and registry number for systematic reviews or meta-analyses. Not applicable. |
| Sustained effects of combined maternal and child SQ-LNS in early life on growth and developmental outcomes at preschool age: an individual participant data analysis of randomized trials in Ghana and Bangladesh.
We observed a sustained impact of maternal plus child SQ-LNS on growth and language development among female children, but not among males. Further research is needed to investigate mechanisms underlying the sex difference in response to nutrient supplementation in early life. The trial in Ghana was registered as NCT00970866 on September 2, 2009 at The trial in Bangladesh was registered as NCT01715038 on October 23, 2012 at |
| Inflamm Bowel Dis |
| Disentangling the gut microbiome and inflammation in inflammatory bowel diseases: longitudinal observations from the IBSEN III study.
The gut microbiome during the first year after IBD diagnosis showed changes that paralleled inflammation and clinical disease activity, albeit without covariation, suggesting that there may be a disease-driving impact of gut microbiome independent of inflammation and inflammation-driven symptoms. |
| Effect of polydeoxyribonucleotide as a potential therapeutic agent to enhance the healing of Crohn's perianal fistula.
PDRN is a potential therapeutic agent that presents a viable option for Crohn's perianal fistula surgery, improving complete fistula closure rate through a safe, cost-effective, and relatively simple procedure. |
| Frailty in inflammatory bowel disease: a missing link in personalized care for the aging IBD population.
Frailty is a critical, under-recognized determinant of poor outcomes in IBD. Systematic screening and integration into care pathways could improve patient stratification and management. Future research should aim to validate specific assessment tools and test interventions to ameliorate frailty in older IBD patients. |
| Longitudinal TCR repertoires in ulcerative colitis patients show features distinguishing disease states.
Overall, these results highlight the importance of analyzing Vβ gene usage and K-mer enrichment in TCR repertoires, particularly given the lack of public clones across patient cohorts. Future studies characterizing the specific antigenic targets associated with these features will pave the way for biomarker discovery in UC. |
| Quality of healthcare delivery in inflammatory bowel disease pregnancy: a scoping review.
Given that IBD has implications for patients during pregnancy, a dedicated exploration of how quality of care may be optimized for this patient group is warranted. In this scoping review, we apply a framework assessing structural, process, and outcome indicators to examine the current quality of healthcare in IBD pregnancy, identify and discuss barriers to achieving quality care, and systematically appraise the existing models used to provide care for IBD patients during their pregnancies. |
| Skin-deep connections: likelihood of skin-scarring history in patients with stricturing/penetrating Crohn disease compared with patients with nonstricturing/nonpenetrating disease and non-inflammatory bowel disease controls.
Patients with stricturing/penetrating Crohn disease had significantly more hypertrophic/keloid scars than those with nonstricturing disease in this cross-sectional proof-of-concept study, suggesting potential shared fibrotic mechanisms between cutaneous and intestinal fibrosis. If corroborated in larger and more longitudinal cohorts, overcoming potential confounders such as postsurgical scars, this novel association may help identify patients at risk and facilitate development of targeted antifibrotic therapies. |
| Transitioning to adult care for patients with IBD: the impact of a structured IBD transition program on service engagement.
Structured transition programs in IBD can improve engagement of patients with IBD services with significantly lower rates of disengagement with IBD services seen in our study. Large prospective studies are needed in this field to further investigate this and the impact of these programs on disease outcomes. |
| Ustekinumab resistance in individuals with ulcerative colitis is associated with an alteration of a subset of proinflammatory mucosal regulatory T cells.
Nonresponse to ustekinumab in UC is linked to a mucosal immune environment enriched with proinflammatory T cell phenotypes and impaired regulatory T cell function. These findings suggest that Tregs are both targets and potential biomarkers of ustekinumab response, with their phenotypic and transcriptional features providing insight into mechanisms of therapeutic resistance. |
| J Crohns Colitis |
| Assessing the impact of delivery method on severe maternal morbidity among individuals with inflammatory bowel disease: a population-based study.
Individuals with IBD were at increased risk of SMM, independent of delivery method. Pregnancy care should focus on optimization of other IBD-related risk factors. |
| Mapping adaptive immune responses toward fungal antigens in inflammatory bowel disease using T cell repertoire sequencing and phage-immunoprecipitation sequencing.
CD is associated with expansion of fungal-specific T cell clonotypes, but S. cerevisiae peptide-based PhIP-Seq reveals limited shared IgG reactivity. Broader antigen libraries and complementary assays capturing glycosylated and virulence-associated fungal epitopes will be needed to comprehensively define antifungal humoral immunity in IBD. |
| Real-world patient characteristics, treatments, and outcomes during and after severe ulcerative colitis hospitalization.
These data from a large contemporary cohort elucidate the burden and outcomes for patients hospitalized with severe UC. |
| Risk of avoidant/restrictive food intake disorders in patients with inflammatory bowel disease: a matched cross-sectional case-control study.
ARFID risk in IBD is nearly twice that of HC and strongly associated with disease activity, malnutrition, and disability, supporting the importance of ARFID screening in routine IBD care. |
| Liver Transpl |
| Comparison of MELD, MELD-Na, and MELD 3.0 scoring systems for transplant prioritization in the turkish population: A multicenter study.
MELD 3.0 and MELD-Na demonstrated superior performance to MELD in predicting 3-month mortality among Turkish liver transplant candidates, though their predictive accuracy was comparable. Further refinements are needed to enhance MELD 3.0's clinical utility. |
| Donor Type, social deprivation, and long‑term outcomes in pediatric liver transplantation: A 30‑year population‑based cohort.
In this population-based cohort study, LDLT was associated with significantly better long-term patient and graft survival and a lower risk of chronic kidney disease compared to DDLT. Socioeconomic disadvantage negatively impacted outcomes primarily among DDLT recipients, highlighting the need to improve equitable access to LDLT and to strengthen targeted post-transplant support for socioeconomically vulnerable families. |
| Pancreas |
| The IL-33/ST2 Signaling Axis Alleviates Splenic Injury in Severe Acute Pancreatitis by Inhibiting T Cell Ferroptosis.
The IL-33/ST2 axis exerts a protective effect in SAP by inhibiting T cell ferroptosis, improving mitochondrial function, and maintaining redox homeostasis, highlighting its potential as a therapeutic target. |
| Pancreatology |
| Identifying risk factors for pancreatic cancer in a large Japanese cohort using an insurance and health check-up database.
Our findings may help prioritize high-risk groups for targeted surveillance and inform the development of risk-stratified early detection strategies for PC. |
| Impact of sarcopenia and myosteatosis on early and long-term survival after surgical resection of pancreatic ductal adenocarcinoma.
Preoperative sarcopenia and myosteatosis are strong predictors of early mortality after PDAC resection, whereas tumor biology determines long-term outcomes. Automated CT-based body composition analysis may support perioperative risk stratification and targeted prehabilitation strategies. |
| Low-molecular-weight heparin and respiratory failure in hypertriglyceridemia-associated acute pancreatitis.
LMWH use may be associated with a lower incidence of respiratory failure in HTG-AP. These findings warrant confirmation in a randomized controlled trial. |
| Pancreatic quantitative sensory testing (P-QST) for pain assessment in Indian patients with chronic pancreatitis.
Cold pressor endurance time was shorter in CP (AIG: 54 vs 74 s, P < 0.001; AIIMS: 103 vs 114 s, P = 0.013). CPM responses were higher in CP (AIG: 5% vs 0%, P = 0.002; AIIMS: 5% vs 3%, P = 0.014) CONCLUSION: P-QST showed consistent, widespread hyperalgesia in Indian patients with painful CP, providing a window of opportunity to identify central sensitization and validating its clinical utility in assessing central pain modulation across diverse populations. |
| Serum GAS6 is useful biomarker for identifying patients with severe acute pancreatitis within 24 h of admission: a multi-cohort analysis of 869 patients.
Serum levels of GAS6 measured within 24 h provide a valuable, rapid approach for identifying SAP, and when combined with established scoring systems, can further improve performance. |
| The impact of targeted next-generation DNA sequencing on the diagnostic accuracy of endoscopic ultrasound-guided tissue sampling of focal pancreatic lesions.
Targeted NGS improves diagnostic accuracy in solid pancreatic lesions and supports surgical decision-making for cystic lesions. Integration of molecular findings into MDTB discussions enhances precision and timeliness of pancreatic cancer treatment. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Inflamm Bowel Dis |
|---|
| Response to: The Long Game in Ulcerative Colitis: Mirikizumab's Four-Year Outcomes. |
| The morphology paradox in pediatric IBD organoids: a path from transcriptomic heterogeneity to clinical utility. |
| J Crohns Colitis |
| AI technologies: transforming global IBD care? |
| Crohn's disease is an obstructive lymphangitis.
Granulomas in downstream lymphatic vasculature cause lymphocyte plugs upstream, followed by lymphangiectasia, edema, stiffening of the part and boggy mucosa. The focal necrosis at the point of granuloma attachment resembles that caused by Chlamydia suis in experimental pigs and murine norovirus in Stat1-deficient mice. |
| Pancreatology |
| Diabetes secondary to chronic pancreatitis and pancreatic cancer: Observations from the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC).
Additionally, we provide updates regarding ongoing work to use clinical and genetic data to model the prediction of incident CP-DM. Lastly, we identify remaining knowledge gaps to further improve the diagnosis and treatment of type 3c diabetes. |
| Dissolving the problem: Biodegradable stents as a value-driven strategy for post-ERCP pancreatitis prophylaxis in high-risk patients. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Inflamm Bowel Dis |
|---|
| Silencing GATA3: DNAzymes enter the therapeutic landscape of ulcerative colitis. |
| J Crohns Colitis |
| Correction to: DOP055 Efficacy and Safety Up to 3 Years of Risankizumab Maintenance Treatment in Patients With Moderately to Severely Active Ulcerative Colitis: Interim Results from Phase 3 COMMAND Open-Label Extension Study. |
| Liver Transpl |
| Clinical outcomes after liver transplantation using donor grafts with SERPINA1 Z heterozygosity. |
| Fellows' Corner. |
| Letter to the Editor: Safe use of living donor right liver graft with dual portal veins. |
| Pancreatology |
| Epidemiological time trends in acute pancreatitis - A 16-year experience from South Australia. |
| Immune dysregulation endotypes in Acute Pancreatitis: Cross-Disease application of the Hi-DEF framework. |
Letters to the editors and authors’ replies
| Pancreatology |
|---|
| IPMN location and malignancy risk: The interplay of embryology, anatomy, and relative duct size.
A 5-mm dilation in the distal pancreas represents a severe relative obstruction compared to the head. We advocate for future guidelines to incorporate relative ductal caliber to optimize surveillance strategies. |
| Response to letter to the editor regarding methodological refinement and microbiome-centric endpoints. |