82 articles - From Friday Sep 18 2026 to Friday Sep 25 2026
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Am J Gastroenterol |
|---|
| HE guidelines in practice. |
| ISOLATED LARYNGOPHARYNGEAL SYMPTOMS DO NOT PREDICT OBJECTIVE REFLUX EVIDENCE: AN INTERNATIONAL MULTICENTER VALIDATION STUDY OF THE SAN DIEGO CONSENSUS PATHWAY FOR SELECTIVE UPFRONT TESTING.
Clinical presentation of isolated LPS is not predictive of LPRD, unlike LPS with typical symptoms. Our findings support the San Diego Consensus recommendations for selective up-front testing in isolated LPS. |
| Clin Gastroenterol Hepatol |
| AGA Clinical Practice Update on the Evaluation and Management of Metabolic Dysfunction- and Alcohol-Associated Liver Disease: Expert Review.
BEST PRACTICE ADVICE 8: Medical management of patients with MetALD and moderate or severe alcohol use disorder should include use of alcohol use disorder pharmacotherapy and behavioral approaches to reduce alcohol consumption. BEST PRACTICE ADVICE 9: Endobariatric and bariatric surgery are not advisable for patients with MetALD due to the lack of safety and efficacy data as well as concerns regarding accelerated liver disease progression with continued alcohol use after surgery. |
| Gastroenterology |
| Methodological Standards for Biliary Drainage Trials in Malignant Distal Biliary Obstruction: An International Consensus. |
meta-analyses and systematic reviews
| Clin Gastroenterol Hepatol |
|---|
| Vedolizumab trough concentrations and clinical and endoscopic outcomes in inflammatory bowel disease: a systematic review and meta-analysis.
Higher VDZ trough concentrations were associated with remission, most robustly for endoscopic remission in UC. As these associations are largely cross-sectional, they may reflect reverse causation rather than a dose-response relationship. Prospective interventional trials are required before proactive TDM can be recommended. |
| Gastrointest Endosc |
| Endoscopic Artificial Intelligence for Invasion-Depth Prediction in Superficial Upper Gastrointestinal Cancer: A Diagnostic Test Accuracy Meta-Analysis.
Endoscopic AI shows clinically meaningful, but validation-dependent, accuracy for invasion-depth prediction, supporting stronger rule-in than rule-out utility for submucosal invasion. Its most plausible near-term role is second-reader support rather than stand-alone determination of ESD candidacy; independent patient-level external validation should be considered essential before clinical deployment. (PROSPERO registration CRD420261400366). |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
|---|
| Carriage of the Laboratory of Genetics and Physiology Protein 2 Q425R Variant Reduces Liver Disease Severity in European Patients With Chronic Hepatitis Delta.
The LGP2 Q425R variant is independently associated with a reduced risk of cirrhosis in European untreated patients with CHD. These results confirm in vivo that enhanced host innate immune responses modulate the natural history of CHD in vivo. |
| Development and Prospective Validation of a Machine Learning-Based Mobile Application (CROHN'S AID) for Differentiating Crohn's Disease From Intestinal Tuberculosis in Tuberculosis-Endemic Regions.
Crohn's Aid represents a step forward in the application of digital health to solve a long-standing clinical dilemma by combining the power of gradient-boosted decision trees with the ubiquity of smartphone technology to reduce misdiagnosis between ITB and CD in resource-limited settings. |
| Medication Use and Risk of Microscopic Colitis: A Propensity-Matched Analysis of US Adults ≥ 50 Years (2014-2024).
In this large cohort, NSAIDs, PPIs and SSRIs were associated with an increased risk of MC, whereas no significant association was observed for ACEIs, ARBs or statins. Medication review should be considered in patients with new-onset chronic diarrhoea. |
| Am J Gastroenterol |
| Alcohol-Use Trajectories and Major Adverse Liver Outcomes in MetALD: A Nationwide Longitudinal Cohort Study.
Alcohol use in MetALD was highly dynamic, and hepatic risk was better captured using longitudinal drinking trajectories. Both intermittent and consistent alcohol reduction were associated with lower MALO risk, with a stronger association for consistent reduction. Consistent reduction was also accompanied by favorable changes in selected cardiometabolic risk factors. |
| COMPARATIVE REAL-WORLD EFFECTIVENESS OF BIOLOGIC THERAPIES FOR PREVENTING POSTOPERATIVE ENDOSCOPIC RECURRENCE OF CROHN'S DISEASE.
In this real-world cohort, biologic prophylaxis is associated with reduced endoscopic recurrence in CD. Both ustekinumab and vedolizumab are effective options, including after prior TNF exposure. |
| Comparison of demographic, clinical, and psychological characteristics among patients with irritable bowel syndrome meeting the Rome clinical, Rome V, and Rome IV criteria.
The Rome clinical criteria identify a clinically meaningful IBS population, with approximately one in five individuals missed by the Rome V criteria. These patients have a disease burden comparable to those meeting the Rome V criteria only. |
| Global Paid and Unpaid Productivity Losses Due to Gastrointestinal Cancer Mortality.
GI cancer mortality causes major global productivity losses; over 40% stems from unpaid work that is often missed by standard estimates and disproportionately borne by females. Better measurement of unpaid work is crucial to developing equitable, gender-responsive cancer policies and healthcare investments worldwide. |
| Life expectancy and changing causes of mortality in familial adenomatous polyposis (FAP).
Recent FAP cohorts now have mortality comparable to the general population. Although colorectal mortality has declined, gastroduodenal and non-FAP-related causes have increased, underscoring the need for continued surveillance and broader long-term management strategies. |
| Long-term Outcomes After Endoscopic Resection for pMM/SM1 Esophageal Cancer: A Multicenter Prospective Cohort Study.
Post-ER pMM/SM1 esophageal cancer is associated with excellent long-term survival. Surveillance is a reasonable option for many LVI-negative cases, although additional treatment may be considered for selected higher-risk patients. |
| Clin Gastroenterol Hepatol |
| Alcohol consumption increases risk of hepatocellular carcinoma in chronic hepatitis B patients.
Alcohol consumption independently increases HCC risk among CHB patients, regardless of cirrhosis status. These findings highlight the importance of systematic assessment and control of alcohol intake to reduce HCC risk in CHB patients. |
| Development and clinical evaluation of the modified Hepatic Encephalopathy Staging Tool.
MHEST is a user-friendly, reliable, and prognostically accurate HE-assessment tool that outperforms West Haven and has been accepted by the U.S. Food and Drug Administration as a clinical trial endpoint. |
| Janus Kinase Inhibitors for Acute Severe Ulcerative Colitis: Comparing Upadacitinib to Tofacitinib and Rescue to Sequential Salvage therapy.
JAK inhibitors were effective for ASUC with a reassuring safety profile. Upadacitinib use resulted in a significantly lower rate of colectomy by week 52, with higher rates of clinical remission, CFCR, and biochemical remission during follow-up. Sequential salvage therapy may represent a viable therapeutic option for patients otherwise facing colectomy. |
| Endoscopy |
| Diagnostic performance of the Japan Narrow-Band Imaging Expert Team and pit pattern classifications for small polyps using next-generation endoscopy.
JNET showed similar observed diagnostic performance across expertise levels, whereas pit pattern classification showed greater between-group differences in sensitivity and negative predictive value. These findings suggest that JNET may serve as a practical framework for routine optical diagnosis of small lesions. |
| Gastroenterology |
| Faecalibacterium prausnitzii EXL01 Strain for the prevention of multiple-recurrent Clostridioides difficile Infection.
A single, well-characterized bacterial strain was associated with restoration of key microbiome functions and low recurrence rates in high-risk rCDI. These findings support precision microbiome therapeutics targeting ecosystem function rather than taxonomic complexity. Controlled trials are ongoing. (clinicaltrials.gov; NCT06306014). |
| Gastrointest Endosc |
| Efficacy and safety of novel VAC-Stent in management of upper gastrointestinal post-surgical leaks: results from a large multicenter study in tertiary referral centers.
VAC-stent GIᵀᴹ represents a safe and effective approach in treating anastomotic leaks following upper GI surgery. |
| Impact of gastric length of myotomy during POEM on the incidence of gastroesophageal reflux: A randomized controlled trial.
SGM significantly reduces the incidence of LA grade ≥B esophagitis at 6 months following POEM, without differences in symptom burden, acid exposure, or clinical efficacy. (ClinicalTrials.gov number, NCT05500196). |
| Gut |
| A durably colonising engineered native symbiont enables sustained intestinal delivery for metabolic dysfunction and colitis.
Design Native murine chassis for sustained intestinal therapeutic delivery. Engineered native symbionts may provide a long-acting live biotherapeutic strategy for metabolic diseases and chronic intestinal inflammation. |
| Coordinated cellular programmes distinguish responses to neoadjuvant PD-L1 blockade and potentiate combinatorial immunotherapy in ESCC.
Overall, our findings unravel the coordinated cellular programmes associated with treatment response, providing insights for prioritising individualised immunotherapy strategies in ESCC. |
| High rates of transition to immune active disease in a cohort of strictly defined immune tolerant patients with chronic hepatitis B: results from the RADICAL consortium.
The majority of this large cohort of well-defined IT patients transition to IA disease within 5 years of follow-up, with the highest risk observed in those with a high-normal ALT, suggesting that these patients may benefit from either more frequent monitoring or pre-emptive therapy. |
| Hospitalisation in cirrhosis is linked to distinct gut microbiome structural and functional profiles: a multinational metagenomic study.
Gut microbiome composition and function are associated with short-term hospitalisation risk and provide additional prognostic information beyond clinical variables in a multicountry cohort. Hospitalisation, regardless of country, is characterised by loss of short-chain fatty acid-producing taxa, functional shifts, ARG and pathway changes. |
| Integrative multi-omics landscape and diagnostic-therapeutic modelling of steatohepatitic hepatocellular carcinoma.
This study provides the first multi-omics characterisation of SH-HCC, highlighting the SH-HCC index and non-invasive diagnostic models, with FABP4 as a potential target. |
| Prior endoscopic surveillance and diagnosis of Barrett-related dysplasia and cancer: evidence from a nationwide Dutch cohort.
In this nationwide cohort, 90% of patients with Barrett-related dysplasia and cancer and 65% undergoing organ-preserving endoscopic treatment had not undergone prior endoscopy. This underscores the need to evaluate whether targeted, evidence-based screening strategies can improve early detection and patient outcomes. |
| Hepatology |
| Hepatitis B virus proteome analysis identifies apolipoprotein C1 facilitating particle production and virus entry.
We established a method for obtaining highly purified HBV virions and fSVPs and identified the HDL component ApoC1 to associate with both particle types. ApoC1 promotes HBV and HDV infection most likely via SR-B1 and facilitates viral entry. |
| Lactulose with or without TeleTai-Chi for the prevention of falls: A sequential multiple assignment randomized controlled trial (LiveSMART).
In patients with cirrhosis and portal hypertension without prior overt HE, lactulose reduced falls and fall-related harms. Sequential lactulose followed by TeleTai-Chi was also superior to enhanced usual care. |
| Safety and efficacy of zetomipzomib in relapsed or insufficiently responding autoimmune hepatitis: Results from the randomized, double-blind, placebo-controlled, phase 2a PORTOLA study and open-label extension.
Zetomipzomib resulted in numerically higher CR rates than placebo, with evidence of steroid-sparing activity in a difficult-to-treat population, and warrants evaluation in larger randomized studies. |
| J Hepatol |
| Restoration of aged liver regeneration by youthful systemic factors via LTβ-driven hepatocyte reprogramming.
Young B-cell-derived LTβ promotes aged liver regeneration by promoting the transient somatic reprogramming of periportal hepatocytes via LTβ/LTBR signaling. Our study highlights the therapeutic potential of LTβ-based strategies to increase regeneration in aging populations. Impact and implications The regenerative capacity of the liver decreases with age, limiting the utilization of elderly grafts. This study demonstrates that youthful systemic circulation rejuvenates aged liver regeneration through young B-cell-derived lymphotoxin β (LTβ), which induces the transient somatic reprogramming of periportal hepatocytes via LTβ/LTBR signaling. These findings are highly relevant to transplant surgeons, hepatologists, and aging researchers. Practically, short-term pharmacological LTBR agonism could be utilized by clinicians to therapeutically "pre-condition" elderly donor livers or enhance post-hepatectomy regeneration in older patients. Furthermore, our work establishes heterochronic transplantation as a powerful clinical research platform to investigate anti-aging mechanisms and rejuvenation strategies across solid organs. |
| J Neurogastroenterol Motil |
| High-resolution Manometry Catheter Insertion During Sedated Endoscopy; A Viable Option When Standard Intubation Fails.
Sedated EI of the HRM catheter enables protocol completion for patients unable to undergo routine testing, filling a key diagnostic gap while delivering manometric results comparable to standard, unsedated studies. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
|---|
| Editorial: Mass Screening for Coeliac Disease-Growing Evidence but Is It Enough? |
| Editorial: Not All Fibres Are Created Equal-Fibre Supplements for Personalised Application. |
| Editorial: Treatment Sequencing in Inflammatory Bowel Disease: Does the Line Matter More Than the Mechanism? |
| Clin Gastroenterol Hepatol |
| Blue Notes. |
| Gastrointest Endosc |
| Are the benefits attributed to Endocut Q for hot snare resection in the colorectum real or myth? |
| Gut |
| Eosinophilic gastritis: burden of disease, diagnostic challenges and unmet needs.
There are currently no approved treatments for EoG, and existing therapeutic options-including dietary elimination and off-label systemic or topical corticosteroids-have suboptimal outcomes or are not appropriate for long-term use. Ongoing clinical studies of biologics in the field have the potential to impact clinical care. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| ACG Workforce of the Future Task Force: A Multidimensional Assessment of GI Workforce Challenges and Recommendations. |
| ACG Workforce of the Future Task Force: Advanced Practice Provider Workforce Subgroup Report. |
| ACG Workforce of the Future Task Force: Physician Workforce Subgroup Report. |
| ACG Workforce of the Future Task Force: The Anesthetizing Task Force Report. |
| Baseline characteristics of a prospective, multi-center study on the natural history of compensated cirrhosis: the Liver Cirrhosis Network. |
| Clin Gastroenterol Hepatol |
| Biliary Obstruction Secondary to Large Peribiliary Varices. |
| Implementing Artificial Intelligence in a Gastroenterology Practice. |
| Endoscopy |
| Barbed suture-assisted tension reduction and de-epithelialization for clip closure of a fecalith-associated rectal fistula. |
| Contrast-enhanced endoscopic ultrasound for vascular mapping: a paradigm shift from target enhancement to danger marking in endoscopic ultrasound-guided biliary drainage. |
| Dual-tunnel endoscopic submucosal dissection for circumferential early gastric cancer involving the pylorus and duodenal bulb. |
| Endoscopic salvage of a complex post-endoscopic mucosal resection duodenal perforation. |
| Multidirectional traction-assisted rectal endoscopic submucosal dissection with prophylactic Glubran 2 nebulization in a high-risk bleeding patient receiving ongoing anticoagulant therapy. |
| Robotic traction-assisted en bloc endoscopic submucosal dissection of early esophageal cancer on the left lateral wall. |
| The "flex-and-resheath" technique for improving transpapillary biopsy of the distal biliary tract. |
| Gastroenterology |
| Comparative Risk of Serious Infections with Biologic Agents and Oral Small Molecules in Inflammatory Bowel Diseases: 2026 Update. |
| Sustained safety and efficacy of entecavir monotherapy for chronic hepatitis B after liver transplantation: 15-year follow-up. |
| Gut |
| Persistent fever and refractory delayed gastric emptying after pancreaticoduodenectomy. |
| Persistent visual disturbance during rescue therapy for acute severe UC. |
| Rapid skeletal muscle loss in cirrhosis: the 'silent killer' within CT imaging. |
| Hepatology |
| From meaningful change to reliable response assessment. |
| J Hepatol |
| Modulation instead of depletion: Rethinking B cell-targeted therapies in IgG4-related cholangitis. |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
|---|
| Editorial: Amino Acid Imbalance and Prognosis in Cirrhosis. Authors' Reply. |
| Editorial: Anti-Integrin αvβ6 Autoantibodies for Distinguishing Ulcerative Colitis From Crohn's Disease: Authors' Reply. |
| Editorial: Association Between Proton Pump Inhibitor Use and Gastric Neuroendocrine Neoplasms in Autoimmune Gastritis-Authors' Reply. |
| Editorial: The Next Frontier in Alcohol-Associated Liver Disease-Integrating Social Determinants of Health Into Risk Stratification and Care Delivery. Authors' Reply. |
| Editorial: Treatment Sequencing in Inflammatory Bowel Disease-Does the Line Matter More Than the Mechanism? Authors' Reply. |
| Letter: Advances in the Diagnosis of Dysplasia in Barrett's Oesophagus-Are We Really Sure It Is Dysplasia? |
| Letter: Does Adherence-Selected Follow-Up Establish the Benefit-Harm Balance of Population Coeliac Disease Screening? |
| Letter: Frail, Not Forgotten: Closing the Loop Between Geriatric Assessment and IBD Care. Authors' Reply. |
| Letter: Methodological and Contextual Considerations for Time to Positivity of a Rapid HBsAg Assay. Authors' Reply. |
| Letter: Reactivation Risk Estimates in HBsAg-Negative Patients-Definitional, Serological, and Reporting Considerations. |
| Letter: Temporal Alignment of Proton Pump Inhibitor Exposure and Gastric Neuroendocrine Neoplasm Risk in Autoimmune Gastritis. |
| Letter: When Does the Risk Clock Start in Immune Checkpoint Inhibitor-Associated Coeliac Disease? |
| Letter: When Survival Improves Without Less Recurrence: What Drives the TDF Advantage After HCC Resection? Authors' Reply. |
| Clin Gastroenterol Hepatol |
| Abdominal Radiography in Pediatric Functional Constipation: Toward a More Nuanced Recommendation. |
| Considerations Regarding the Optimal Retention Duration of Prophylactic Pancreatic Duct Stents. |
| Four-Week Assessment of Prophylactic Pancreatic Stents: Reduced Endoscopy, but Is Safety Established? |
| Letter to the Editor re: A Randomized Trial of Rifaximin vs Low FODMAP Diet. |
| Gastroenterology |
| Rectal NSAIDs for ERCP: Rethinking Renal Safety with Drug-Specific Considerations. |
| Regarding "Cardiovascular Outcomes Following Major Gastrointestinal Bleeding in Patients With Pre-Existing Cardiovascular Disease: The INTERBLEED International Prospective Cohort Study". |
| When the Beat and the Bleed Compete: An Opportunity for INTERBLEED Subgroup Analysis in Patients With Liver Cirrhosis. |
| Gut |
| Cryptogenic steatotic liver disease: the peril of categorical thresholds in diverse populations. |
| Single-nucleus transcriptomics refine the hepatic cellular context of the MASLD proteosurvival signature. |