85 articles - From Friday Jul 24 2026 to Friday Jul 31 2026
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Gastrointest Endosc |
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| Closing the completion colonoscopy gap: key takeaways from the American Society for Gastrointestinal Endoscopy's 2025 National Colorectal Cancer Screening Summit. |
| Improving follow-up of abnormal stool test results used for colorectal cancer screening.
The current article reviews the barriers to timely colonoscopy, highlights evidence-based interventions, and provides actionable recommendations for endoscopists, health systems, and policymakers. By implementing coordinated strategies, including patient navigation, digital tools, and open access colonoscopy, health care organizations can close critical gaps in the CRC screening continuum and decrease CRC incidence and mortality. |
| J Neurogastroenterol Motil |
| Gastroesophageal Reflux Disease and Reflux-like Phenotypes: Using Lyon Consensus 2.0 to Guide Clinical Approach.
Hypervigilance and symptom-specific anxiety can overlap with al the phenotypes, and E-DGBI can coexist with conclusive GERD. Therefore, there are intricate interrelationships between Montreal, Lyon and Rome criteria that aid evaluation of troublesome symptoms, and concepts from each of these contribute to accurate phenotyping and optimal management of patients. |
meta-analyses and systematic reviews
| Endoscopy |
|---|
| Immediate vs Step-up Endoscopic Transluminal Necrosectomy in Necrotizing Pancreatitis: Systematic Review and Meta-analysis of Randomized Controlled Trials.
Immediate DEN was associated with higher clinical success and shorter hospital stay compared with a step-up strategy. These findings support selective consideration of immediate DEN in appropriate patients with WON, while timing remains individualized. |
| J Neurogastroenterol Motil |
| Potassium-competitive Acid Blockers in Gastroesophageal Reflux Disease and Functional Dyspepsia: A Korean Expert Review With Original Meta-analyses.
Limited clinical and real-world data indicate that second-generation P-CABs do not exhibit significant hepatotoxicity, however, long-term hypergastrinemia and mucosal changes warrant further surveillance. This review highlights the evolving role of P-CABs in gastroesophageal reflux disease and FD and emphasizes the need for further research to refine their clinical positioning, optimize therapeutic strategies, and evaluate long-term safety outcomes. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
|---|
| Clinical Trial: Phase 3 Trial of Resmetirom Versus Placebo in Metabolic Dysfunction-Associated Steatohepatitis-Reanalysis of Fibrosis Stage 2-3 Subset.
Results among patients with F2 and F3 fibrosis were consistent with the primary MAESTRO-NASH analysis population, demonstrating efficacy and safety of resmetirom after 52 weeks. |
| Endoscopy |
| Spiral basket geometry improves procedural efficiency and reduces device escalation in small bile duct stones: a multicenter randomized controlled trial (ESCAPE trial).
A spiral basket configuration improved early procedural efficiency and reduced device escalation and device-related costs, without improving the final stone-clearance rate or increasing adverse events. The spiral basket was not compared with balloon extraction and should not be interpreted as superior to it. Although the device evaluated is currently available primarily in Japan, the geometric principle underlying its advantage may inform device development more broadly. (UMIN000055497). |
| Gastroenterology |
| AI-Assisted Risk Stratification in Stage II Colorectal Cancer: Multi-Institutional Validation of Semantically-Enhanced Deep Learning.
SÉMIL demonstrates validated prognostic stratification in stage II colorectal cancer, with potential utility for refining risk assessment within NCCN guideline-defined high-risk categories where treatment decisions are most challenging. |
| Gastrointest Endosc |
| Association between colonoscopy and colorectal cancer risk in adults aged 75 to 85 years: a nationwide population-based cohort study.
Colonoscopy was associated with reduced CRC incidence in adults aged 75 to 79, but not 80 to 85, particularly women. These findings highlight the need for individualized screening considering life expectancy and competing risks in older adults. |
| Combined prophylactic vessel coagulation and high-density complete defect closure after colorectal endoscopic submucosal dissection.
Combining prophylactic vessel coagulation with high-density complete defect closure after colorectal ESD significantly reduces delayed bleeding, composite DAEs, and unplanned readmissions, supporting its role as an effective strategy to enhance post-ESD safety. |
| Diagnostic Performance and Feasibility of the CC100 Colon Capsule Endoscopy System: A Prospective Multicenter Study.
This prospective multicenter study demonstrates that a next-generation CCE system can achieve acceptable examination completeness and clinically meaningful diagnostic concordance with colonoscopy. |
| Endoscopic Ultrasound and Clinical Features for Differentiating Autoimmune Pancreatitis and Pancreatic Ductal Adenocarcinoma: A Multicenter Cohort Study.
Combining EUS features with clinical and serological variables yields more balanced diagnostic performance for differentiating AIP from PDAC than either modality alone. Given the retrospective design, risk of overfitting, and lack of independent external validation, prospective validation is required prior to routine clinical implementation. |
| Esophagogastric Junction Marking Clip Placement During Endoscopic Ultrasound-Guided Hepaticogastrostomy: A Single-Center Retrospective Study.
Routine EGJ marking clip placement during EUS-HGS may help avoid transesophageal puncture and high technical and clinical success rates. This simple technique may improve procedural safety, particularly during the early learning phase of EUS-HGS, without the need for specialized equipment. Clinical trial registration |
| Peroral Endoscopic Myotomy for Pediatric Achalasia: 36-Month Outcomes from a Single-Center Cohort Study.
POEM appears to be a safe and effective treatment for pediatric achalasia, with favorable outcomes sustained at 36 months. |
| Peroral Endoscopic Myotomy versus Flexible Endoscopic Septotomy for Zenker's Diverticulum: A Cost-Effectiveness Analysis.
Over a 12-month time horizon, FES appears to be the economically preferred strategy for the treatment of ZD. Although Z-POEM is clinically effective, its higher upfront costs limit short-term economic value. However, when longer-term outcomes are incorporated, Z-POEM may become cost-effective over a 24-month horizon, driven by improved durability and lower recurrence compared to FES. |
| Gut |
| Galectin-14, a primate-specific oncofetal protein, impairs anti-tumour immunity in hepatocellular carcinoma by driving elevated heparan sulphate modification.
This study defines galectin-14 as a key oncofetal regulator of HCC immunosuppression by rewiring UGP2-mediated glycosyl donor production to promote elevated HS modification and T cell dysfunction, highlighting a potential diagnostic marker and promising therapeutic avenue in HCC. |
| Impact of initial severity and progression pattern of new-onset diabetes on pancreatic cancer risk: a 15-year longitudinal nationwide cohort study.
Greater initial severity of NOD and rapid early aggravation were both associated with an increased risk of pancreatic cancer. |
| In-person therapist-delivered hypnotherapy versus smartphone-based self-guided hypnotherapy in IBS: a multicentre three-armed randomised controlled trial.
This multicentre RCT could not demonstrate non-inferiority of smartphone-based self-guided hypnotherapy compared with in-person therapist-delivered hypnotherapy in reducing abdominal pain. However, substantial response rates for smartphone-based self-guided hypnotherapy highlight its potential as a broadly applicable and cost-effective alternative. |
| Macropinocytosis of neutrophil extracellular trap by gastric cancer cells promotes immune escape and peritoneal metastasis.
We highlight the importance of macropinocytosis mediated uptake of NETs in GC immune escape and PM recurrence, providing a potential combination therapeutic strategy for patients with PM. |
| Proteomic resolution of the MASLD cardiometabolic spectrum identifies sex-driven endotypes and predicts systemic mortality.
MASLD-driven proteomic shifts reflect biological pathways that connect hepatic metabolic dysfunction with long-term survival. By resolving the MASLD cardiometabolic spectrum, we identified high-risk endotypes that are not captured by traditional liver-centric scores. The PS4 represents a biologically grounded framework for deciphering the systemic consequences of MASLD. |
| Ustekinumab for fistulising perianal Crohn's disease: a randomised placebo-controlled trial from the GETAID.
These findings suggest greater short-term clinical benefit with UST compared with placebo and support its use in patients with active fistulising perianal CD. |
| Hepatology |
| Implications of new obesity definitions in the classification and outcomes of patients with MASLD.
New obesity definitions broadened the obesity population but did not improve LRE prediction over BMI alone. Higher waist-based thresholds warrant further evaluation. |
| J Hepatol |
| An ABC approach for preoperative staging in perihilar cholangiocarcinoma An international multicenter cohort study.
Following the ABC system, we should be reluctant to offer resection to patients with an ABC score of 3 with a tumor size ≥25 mm, CA19-9 ≥500 U/mL, and a WHO PS ≥1. |
| Non-selective β-blockers reduce bacterial translocation by restoring gut barrier function during experimental cirrhosis.
Sustained β-adrenergic hyperstimulation disrupts the multi-layer intestinal barrier, promoting pathological bacterial translocation in cirrhosis. Propranolol restores barrier integrity through mechanisms involving endothelial VE-cadherin stabilisation, at least partly independent of microbiota changes and haemodynamic effects. |
| J Neurogastroenterol Motil |
| Confocal Laser Endomicroscopy With Duodenal Food Challenge Does Not Predict Triggering Food Items in Eosinophilic Esophagitis: Results From a Pilot Trial.
In this pilot blinded cross-over trial, a targeted elimination diet based on the results of CLE with DFC did not generate a superior response compared to a sham diet. |
| Disorders of Gut-Brain Interaction and Psychological Comorbidity in Singapore: Insights From the Rome IV Global Epidemiology Study.
In Singapore, DGBI are common but less prevalent than global estimates. Constipation-related disorders and psychological comorbidities contribute substantially to symptom burden and healthcare use, particularly in women and younger adults. Findings support integrated, culturally tailored care pathways to guide regional practice and public health policy. |
| Ineffective Esophageal Motility and Its Predictors in Gastroesophageal Reflux Disease Patients with Pathologic Acid Exposure Time.
In GERD patients with confirmed pathological acid exposure, IEM is common and associated with weakened LES pressure, delayed peristalsis, and reduced mucosal integrity. The link between low MNBI and IEM suggests an interaction between epithelial barrier dysfunction and esophageal motility, emphasizing the need for comprehensive functional evaluation in GERD management. |
| Machine Learning Clustering Identifies Achalasia-Spectrum Phenotypes in Distal Esophageal Spasm.
Machine learning clustering successfully identified a DES phenotype characterized by high premature contraction frequency that clusters with type III achalasia. Premature contraction frequency may serve as a clinical marker for selecting DES patients for lower esophageal sphincter-directed therapies. Given the rarity of DES, larger validation studies are needed to confirm these findings. |
| Morphological, Molecular and Motility Changes in Human Small Intestine After Loop Ileostomy.
Although morphological, molecular and motility changes including down-regulation of contractile protein expression were observed in the distal loop, number of PDGFRα + cells, ICCs, and neuronal cells were preserved. These results may explain restoration of the bowel motility after ileostomy take-down with low incidence of ileus. |
| Possible Mechanisms Underlying the Effects of Fecal Microbiota Transplantation in Patients With Irritable Bowel Syndrome.
Stem cells, enteroendocrine progenitors, serotonin, and glucagon-like peptide 1 as well as low-grade inflammation may play roles in IBS symptom manifestations. The effects of FMT are probably due to the amelioration of these abnormalities. |
| The Association Between Usual Diet and Bowel Disorders of Gut-Brain Interaction: Analyses From the Rome Foundation Global Epidemiology Study.
Though complicated by variations in results between the 2 survey populations, this global survey has revealed dietary factors that may impact, in the general population, on reported prevalence rates for DGBI. |
| The Effects of Physical Activity on Functional Dyspepsia: A Mendelian Randomization and Randomized Controlled Study.
PA, particularly moderate-intensity exercise, may reduce the risk of FD. |
| The Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols Diet Is Effective in Irritable Bowel Syndrome With Constipation: A Single Center Tertiary Care Clinical Practice Evaluation.
IBS-C and IBS-D showed similar symptom relief after FODMAP restriction. Notably, 44.9% of IBS-C patients shifted to normal stool consistency (IBS-U), with greater symptom relief and reduced pain. FODMAP restriction does not necessarily exacerbate constipation in IBS-C and remains a viable treatment option in real world clinical practice. |
| The Utility of the Functional Sphincter Area: A Novel Functional Lumen Imaging Probe Parameter for the Assessment of Anal Sphincter Structure and Function in Fecal Incontinence.
The FSA may offer a clinically useful parameter and, in combination with other FLIP measurements, could become a useful tool to assess the structure and function of the anal canal in FI. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
|---|
| Review Article: Accelerating Coeliac Disease Clinical Trials-Beyond Celiac Meeting With Industry, Academics, Patients and the FDA.
addressed the ideal length of the double-blind period, including a shorter 24-week double-blind study with an open-label extension versus a 52-week double-blind design. Trial duration should balance scientific rigour, patient retention, and the need for longer-term safety and durability data, with flexibility to tailor the approach to context. Conclusions Progress in coeliac disease drug development will require patient-centred, scientifically robust but feasible trial designs with appropriate endpoints, justified use of gluten exposure, consideration of improved biomarkers to reduce patient burden and early regulatory engagement. Continued multi-stakeholder collaboration, including dedicated consideration of paediatric drug development, is essential to advance effective therapies. |
| J Hepatol |
| A framework and shared vocabulary to identify actionable protein biomarkers and enable optimal precision medicine: Myth-Busting with Unicorn Biomarkers.
We propose that minimum technical and biological standards must be met before a molecular measurement can be designated a "biomarker", beyond minimal criteria of association between biological signal and disease state. By raising the bar with Unicorn Biomarkers, this framework aims to guide researchers, regulators, and industry stakeholders in identifying actionable biomarkers and advancing precision medicine. |
| Fibrosis regression in chronic liver disease: the pathologist's view.
The clinical significance of regressive features is hitherto unstudied. In this brief review, we are addressing shortcomings in (i) the histological assessment of fibrosis regression across the whole spectrum of common chronic liver diseases and (ii) identification of a point of no return in advanced fibrosis and argue that the hepatopathologists' community should rise to such challenges, perhaps hastened by development of artificial intelligence solutions applied to liver biopsies. |
| IL-19 limits macrophage-driven inflammation in acetaminophen-induced liver injury. |
| Pushing the boundaries of liver resection for liver cancer.
Furthermore, a deeper knowledge of surgical oncological principles combined with integrative strategies, including systemic and locoregional therapies, has enabled downstaging and conversion of initially unresectable liver malignancies, expanding surgical eligibility across a growing spectrum of hepatic tumoural conditions. Additionally, advances in the understanding of molecular biology and new treatment strategies, particularly in iCCA, have the potential to further extend the boundaries of resectability. |
| The hepatocellular carcinoma wish list: Five aspirations for future care. |
| J Neurogastroenterol Motil |
| Advances in Understanding Calcium Sensitization in Gastrointestinal Smooth Muscles: Pathways, Interstitial Cells, and Disease.
This review updates our current understanding of the regulatory mechanisms of calcium sensitization with the recent findings from genetically engineered mice with deficiencies in protein kinase C and ROCK2 calcium sensitization pathways, and the involvement of interstitial cells in regulating GI smooth muscle cell excitability. Dysregulated calcium sensitization pathways in motility disorders are summarized, to potentially aid in the development of new pharmacological strategies to prevent and treat GI motility disorders. |
| Belching and Reflux: The Relationship and the Underlying Mechanism. |
| Beyond Dysbiosis Restoration: Does the Success of Fecal Microbiota Transplantation for Irritable Bowel Syndrome Lie in Repairing the Intestinal Stem Cell Niche? |
| Physical Activity as a Therapeutic Strategy for Functional Dyspepsia. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| Calendar of Courses, Symposiums and Conferences. |
| Letter to the Editor. |
| Necrotizing giant cecal diverticulitis as an unusual cause of severe lower gastrointestinal bleeding. |
| Seeing Beyond Inflammation: Radiomics and the Quest to Measure Fibrosis in Crohn's Disease. |
| Clin Gastroenterol Hepatol |
| Outcomes following esophageal hydraulic dilation in patients with disorders of esophagogastric junction outflow. |
| Robust Performance Metrics of the Capsule-Sponge-Trefoil-Factor-3 Test for Detecting Barrett's Esophagus: A Pooled Analysis. |
| Step-Down Dose Reduction Dupilumab Maintenance is an Effective Long-Term Treatment Strategy in Eosinophilic Esophagitis. |
| Endoscopy |
| A nasobiliary catheter landmark technique for endoscopic ultrasound-guided gallbladder drainage in patients with Billroth II anatomy: A case series. |
| An "uncovered stent-in-covered stent" technique combined with electrohydraulic lithotripsy for the removal of a displaced type B (metal) bile duct stent stone complex. |
| Detection of an intraductal component of a pancreatic ductal adenocarcinoma using a novel ultrathin pancreatoscope. |
| Direct‑vision peritoneal access as salvage for guidewire loss during endoscopic ultrasound‑guided hepaticojejunostomy. |
| Endoscopic removal of an impacted common bile duct stone and subsequent procedures using two devices passed simultaneously through a device delivery system. |
| Endoscopic retrieval of a fragile foam foreign body at the rectosigmoid junction using an improvised lithotripter-guidewire retrieval device. |
| Endoscopic sleeve gastroplasty and pharmacotherapy: bridging the therapeutic gap or redefining bariatric care? |
| Endoscopic ultrasound-guided gastroenterostomy using direct needle-puncture for complete pyloric obstruction. |
| Endoscopic ultrasound-guided radiofrequency ablation of a mediastinal lymph node metastasis from clear cell renal cell carcinoma. |
| Firm lesion consistency and whitish tissue exposure in gastrointestinal Langerhans cell histiocytosis. |
| Inadvertent dislodgement of a biliary metallic stent during duodenal stent placement. |
| Long-cap compression hemostasis for puncture-site bleeding after endoscopic injection sclerotherapy: from rescue therapy to routine practice. |
| Non-intubated esophageal underwater endoscopic submucosal dissection: "one-way flow" via stiffened orogastric drainage. |
| Prophylaxis of esophageal stricture after endoscopic submucosal dissection with autologous adipose-derived stromal cells. |
| Salvage endoscopic submucosal dissection via a continuous irrigation method for locally recurrent esophageal cancer after photodynamic therapy. |
| Successful cholangioscopic retrieval of a completely migrated stent in the gallbladder following endoscopic transpapillary gallbladder drainage. |
| Successful management of esophagomediastinal fistula postsubmucosal tunneling endoscopic resection using a "three-tube" approach. |
| Traction-assisted endoscopic submucosal dissection for a terminal ileal neuroendocrine tumor. |
| Gastrointest Endosc |
| Best of ERCP 2026. |
| Best of endoscopic submucosal dissection 2026. |
| Gut |
| A patient-driven agenda for liver cirrhosis research. |
| Toward a CKLM framework for integrated clinical trial design. |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
|---|
| Editorial: A New Insert Device for Faecal Incontinence-To Use or Not to Use? Author's Reply. |
| Letter: External Validation of Hepcidin Thresholds for Predicting Response to Iron Therapy in Active Inflammatory Bowel Disease. |
| Letter: Frail, Not Forgotten: Closing the Loop Between Geriatric Assessment and IBD Care. |
| Letter: Interpretation of Cognitive and Clinical Outcomes in the Randomized Trial of Rifaximin for Covert Hepatic Encephalopathy. Authors' Reply. |
| Letter: SCFA Enrichment in IBS-D-A Disease Subtype or a Transit-Driven Phenomenon? |
| Gastroenterology |
| Concern Regarding the Events-per-Variable Ratio in a Persistence Analysis of Irritable Bowel Syndrome. |
| Gut |
| Colonoscopy compliance matters more than time to colonoscopy after a positive FIT result. |
| J Hepatol |
| Letter: Validation of the international multisociety diagnostic scoring system for PSVD/NCPF in a Chinese cohort. |
| J Neurogastroenterol Motil |
| Functional Dyspepsia and Gastric Emptying Scintigraphy: Why 4-Hour Imaging and a 255-kcal Meal Matter. |
| Preoperative Esophageal Physiologic Testing in Bariatric Surgery: How Far Should We Go? |
| Reinterpreting Amitriptyline in Extra-esophageal Gastroesophageal Reflux Disease Through the GABAergic Inhibitory Axis. |
| Symptomatic Inlet Patch as a Cause of Chronic Cough and Dysphagia: A Case Report. |