82 articles - From Friday May 22 2026 to Friday May 29 2026
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Gastroenterology |
|---|
| Consensus on Irritable Bowel Syndrome-like Symptoms in Inflammatory Bowel Disease: A Step Toward Advancing Patient-Centered Care. |
| Hepatology |
| A multisociety consensus statement on a new common definition and diagnostic criteria for PSVD or NCPF.
This consensus provides the first internationally endorsed, unified framework for the diagnosis of PSVD or NCPF. Its global implementation is expected to reduce diagnostic variability, improve comparability across regions, and facilitate the development of robust, internationally harmonized clinical and translational research cohorts. |
| J Hepatol |
| A multisociety consensus statement on a new common definition and diagnostic criteria for PSVD or NCPF.
This consensus provides the first internationally endorsed, unified framework for the diagnosis of PSVD or NCPF. Its global implementation is expected to reduce diagnostic variability, improve comparability across regions, and facilitate the development of robust, internationally harmonized clinical and translational research cohorts. |
| EASL position paper on preclinical models of steatotic liver disease.
These criteria encompass systemic and hepatic metabolism, cardiometabolic comorbidities, histopathology, immunopathology, and molecular features relevant to disease stage and aetiology. This position paper aims to guide informed model selection, promote consistent nomenclature, and enhance rigour and translational relevance in preclinical and experimental SLD research. |
| EASL-AASLD Delphi consensus statement on surrogate endpoints and real-world evidence in primary biliary cholangitis.
The Delphi process resulted in agreement on 16 statements and 42 recommendations across the three thematic domains. Collectively, these consensus recommendations provide a comprehensive and pragmatic framework to support and expand the existing regulatory pathway for the development and approval of new therapies in PBC. |
meta-analyses and systematic reviews
| Am J Gastroenterol |
|---|
| Endoscopy-based Deep Learning Algorithms versus Endoscopists in Early Esophageal Squamous Cell Carcinoma Detection: A Systematic Review and Meta-Analysis.
Endoscopy-based DL shows high accuracy for early ESCC detection and appears to outperform endoscopists overall, especially juniors, while also enhancing both groups' performance. Current evidence does not demonstrate DL surpassing senior endoscopists. Prospective, multicenter studies across diverse populations are warranted. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
|---|
| Incidence of Hepatitis B Virus Reactivation in Patients Treated With Immunosuppressive and Chemotherapeutic Agents.
HBVr incidence was quantified across a broad range of immunosuppressive and chemotherapeutic therapies, including those with previously limited incidence data. The observed incidence patterns were broadly consistent with current guideline-based risk stratification, while also highlighting measurable risk in some therapies traditionally considered lower risk. |
| Prevalence and Burden of Fatigue Across Disorders of Gut-Brain Interaction: Results From the Rome Foundation Global Epidemiology Study.
Fatigue is common and burdensome in DGBI, particularly with overlapping diagnoses. Given the cross-sectional design, directionality between fatigue and DGBI symptom burden remains unclear. Future research should employ longitudinal fatigue assessments to inform targeted management. |
| Risk Prediction of Early-Onset Hepatocellular Carcinoma: Derivation and Validation in a Nationwide Young Adult Cohort.
We developed and validated robust risk prediction models for eHCC that integrated established risk factors with emerging metabolic indicators. This study provides actionable tools for risk stratification in young adults to address the growing burden of eHCC. |
| Socioeconomic Inequalities in Receipt of Curative-Intent Treatment and Survival After Surveillance-Detected Hepatocellular Carcinoma: A Nationwide Cohort Study.
Socioeconomic inequalities in the receipt of curative-intent treatment and survival persist even among individuals with surveillance-detected HCC within a universal healthcare system. These findings indicate that surveillance alone is insufficient to ensure equitable outcomes and underscore the need for regionally tailored, people-centred strategies that address social vulnerability across the HCC care continuum. |
| Temporal Association Between COVID-19 Vaccination and HBsAg Loss in Chronic Hepatitis B Infection: An Interrupted Time Series Analysis.
COVID-19 vaccination was temporally associated with transiently higher HBsAg loss rates in CHB, followed by attenuation, suggesting a potential population-level immunomodulatory effect on HBV dynamics. |
| Am J Gastroenterol |
| Communicating Risk and Safety of Inflammatory Bowel Disease Therapies.
Corticosteroid use is the major driver of serious infection, VTE, and MACE, while combination anti-TNF-thiopurine therapy, JAK inhibitors, and S1P receptor modulators are associated with therapy- and context-specific infectious and thrombotic risks, which remain low in absolute terms for most patients. Across outcomes, we emphasize absolute risk and patient-level modifiers, and provide pictorial tools that depict clinically meaningful risks to support shared decision-making and individualized, evidence-based risk communication with patients. |
| Esophageal clearance assessed by high-resolution impedance manometry in achalasia: a prospective study with 1-year follow-up.
HRiM is a reliable, reproducible tool for assessment of esophageal clearance post-POEM.(Clinicaltrial.gov, NCT06230536). |
| Increased risk of hypoglycemia in children and young adults after undergoing bowel preparation for colonoscopy.
Children and young adults undergoing colonoscopy bowel preparation have a significant risk of hypoglycemia, especially those who are younger and with lower weight percentiles. Routine pre-procedure screening for hypoglycemia and implementation of preventative interventions during bowel preparation may be beneficial in the pediatric population. |
| Clin Gastroenterol Hepatol |
| Combined Upadacitinib and Vedolizumab as 8-Week Induction Therapy for Moderate-to-Severe Ulcerative Colitis: A Multicenter, Randomized Controlled Trial.
In this open-label trial, combined upadacitinib and vedolizumab induction was superior to vedolizumab monotherapy for achieving endoscopic and clinical remission at week 8 in patients with moderate-to-severe ulcerative colitis. Although these findings should be interpreted with caution given the early trial termination and open-label design, they provide the first randomized evidence supporting a short-term combination biologic and small-molecule induction strategy. (ClinicalTrials.gov number, NCT06095596 ). |
| Hepatic Steatosis Is Associated With Increased Cardiovascular Risk Through Adverse Coronary Plaque Composition: Insights from the PROMISE Trial.
Hepatic steatosis was associated with greater NCPB and increased MACE risk, with NCPB accounting for a portion of this association, suggesting a link between hepatic steatosis and vulnerable coronary atherosclerosis. These findings support integrated cardiometabolic risk assessment in patients undergoing coronary CT angiography. |
| Predicting decompensation in unresectable hepatocellular carcinoma on atezolizumab plus bevacizumab: the ARTE Score.
The ARTE-score is an easy-to-use tool to predict hepatic decompensation in uHCC, aiding clinical decision-making. |
| The TECCU-based telemonitoring platform for Inflammatory Bowel Disease is Cost-Effective: A Multicenter GETECCU Trial.
Telemonitoring with the TECCU app reduces healthcare and societal costs while maintaining disease control, demonstrating its cost-effectiveness as a complementary strategy to standard care on a nationwide scale. |
| Endoscopy |
| Computer-Assisted and Unassisted Optical Diagnosis of Colorectal Polyps: Results from a Prospective Pragmatic Implementation Study.
In a real-world descriptive implementation study, CADx-assisted and CADx-unassisted optical diagnosis showed good diagnostic performance. Assessment of the relationship between CADx use and optical diagnosis was limited by unavoidable selection bias related to discretionary use and variable endoscopist behavior despite adjusted analyses. |
| Gastroenterology |
| Targeting oncomucin-driven immunosuppression improves the efficacy of K-ras<sup>G12D</sup> inhibition in pancreatic cancer.
Transmembrane oncoMUCs promote immune evasion in PDA through EGFR/UNC5B signaling, and their targeting enhances the efficacy of K-ras G12D inhibition, suggesting oncoMUCs as novel immune regulators and therapeutic targets in PDA. |
| Gastrointest Endosc |
| Virtual crystal violet chromoendoscopy: a digital alternative to dye-based staining.
AI-based vCV chromoendoscopy can replicate the diagnostic interpretability of conventional CV staining without dye application. |
| Gut |
| Blocking MOXD1-derived ACOX1 peroxisome trafficking suppresses metabolic dysfunction-associated steatohepatitis.
This study identifies MOXD1 as a previously unrecognised regulator of hepatic fatty-acid homeostasis and a key driver of MASH pathogenesis. Targeting the MOXD1-ACOX1 axis offers a promising therapeutic strategy for MASH. |
| PTEN deficiency impairs MHC-I-mediated tumour immunity via NRF2-dependent autophagy in microsatellite stable colorectal cancer.
PTEN deficiency promotes immune evasion in MSS CRC via an NRF2-dependent axis that triggers autophagy-mediated degradation of MHC-I. Targeting NRF2 represents a promising strategy to enhance the efficacy of immunotherapy in PTEN-deficient MSS CRC. |
| J Hepatol |
| Liver-directed lentiviral gene therapy confers durable hepatic and systemic amelioration of methylmalonic acidemia in mice.
These data provide preclinical proof-of-concept for the efficacy, safety, and extrahepatic therapeutic benefit of liver-directed LV gene therapy for MMA. Impact and implications Methylmalonic acidemia (MMA) is a severe metabolic disorder with few treatment options. A liver-targeted gene therapy using integrating lentiviral vectors (LV) could allow treatment of pediatric patients with a single dose, due to the stable integration of the therapeutic transgene into the DNA of target cells. In this study, we showed that in a relevant MMA mouse model, systemic LV administration led to long-lasting expression of the therapeutic enzyme in hepatocytes, which corrected metabolic abnormalities and significantly improved the disease phenotype. Supranormal enzyme levels in the liver enabled systemic detoxification and widespread metabolic normalization without detectable LV-related toxicity. We provide a detailed LV dose-response study evaluating the efficiency of gene transfer to hepatocytes and its therapeutic outcomes. Overall, these findings offer strong preclinical evidence to support progressing to clinical trials for MMA patients and help guide the potential use of liver-directed LV gene therapy for other inherited metabolic diseases. |
| MARCHF6 orchestrates hepatic lipid homeostasis by targeting SREBP1 for ER-associated degradation.
MARCHF6-ERAD is a critical regulator of hepatic lipid metabolism, functioning as a sterol binding protein to control SREBP1 turnover. Its downregulation promotes hepatic steatosis and MASLD progression, highlighting MARCHF6 as a potential therapeutic target for MASLD intervention. Impact and implications This study identifies the ER-resident E3 ubiquitin ligase MARCHF6 as a key regulator of SREBP1 stability, hepatic lipid homeostasis and MASLD progression. We demonstrate that loss of MARCHF6 promotes hepatic steatosis and fibrosis, whereas restoration of MARCHF6 largely reverses these phenotypes, highlighting a reversible and therapeutically targetable pathway. These findings provide new mechanistic insight into lipid dysregulation in MASLD and position the MARCHF6-SREBP1 axis as a promising target for metabolic liver disease intervention. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
|---|
| Editorial: Do We Need to Adapt GERD Metrics Based on the Population Being Evaluated? |
| Editorial: Liver and Non-Liver Outcomes Between Different Subtypes of Steatotic Liver Disease. |
| Editorial: Silent But Detectable-High-Throughput Proteomics to Identify Clinically Significant Liver Disease. |
| Editorial: Spontaneous Bacterial Peritonitis-Redrawing Empiric Therapy in the Era of Multidrug Resistance. |
| Editorial: Two Common Risks, One Greater Harm-Diabetes and Alcohol in Steatotic Liver Disease. |
| Clin Gastroenterol Hepatol |
| Blue Notes. |
| Promoting High-Quality Palliative Care for Minoritized Sexual and Gender Identity Populations With Advanced Liver Disease. |
| Gut |
| Autoimmune gastritis: a hidden gateway to cardia and oesophageal cancers beyond non-cardia gastric adenocarcinoma.
Finally, we outline a research agenda aimed at clarifying the malignancy risk across the stomach-cardia-oesophagus continuum, emphasising the need for well-phenotyped cohorts, biomarker-driven risk stratification and refined surveillance strategies. By reframing AIG as a potential hidden gateway to junctional and oesophageal malignancies, we argue that its true oncological significance may be broader than previously appreciated. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| CBT for Pediatric Functional Abdominal Pain: Time to Rethink Traditional Assumptions? |
| From Prenatal Exposure to Disease Risk: Insights and Limits of n-3 Fatty Acid Studies in Celiac Disease. |
| How I Approach Refractory Constipation Symptoms. |
| Letter to the Editor. |
| Clin Gastroenterol Hepatol |
| Upadacitinib achieved rapid response in biologic-refractory immune checkpoint inhibitor-related enterocolitis. |
| Endoscopy |
| A novel endoscopic ultrasound system assisted by artificial intelligence for the recognition of pancreatic parenchyma and the detection of solid/cystic lesions. |
| Application of a novel peaked transparent cap to assist in rectal endoscopic submucosal dissection. |
| Beyond cleansing adequacy: work and patient-reported outcomes in bowel-preparation trials. |
| Beyond glue injection: rethinking strategy in gastric variceal bleeding. |
| Endoscope-assisted single-port intragastric surgery for gastric submucosal tumors in the fornix. |
| Endoscopic retrieval of an N-butyl-2-cyanoacrylate cast from the common bile duct: a rare complication of portal vein embolization. |
| Endoscopic ultrasound-guided duodenojejunostomy for recurrent malignant duodenal obstruction after surgical gastrojejunostomy. |
| Endoscopy E-Videos - recently published. |
| From local to systemic: endoscopic findings reshape the diagnostic paradigm of satoyoshi syndrome - a case report. |
| Gallbladder perforation during peroral holmium laser lithotripsy. |
| Guidewires and biopsy forceps: a novel approach for appendiceal orifice closure in endoscopic retrograde appendicitis therapy. |
| Mixed-reality-based remote endoscopic retrograde cholangiopancreatography education using a three-dimensional anatomical model. |
| Muscle-clipping suturing for closure of a gastric defect after endoscopic submucosal dissection for a type 3 neuroendocrine neoplasm. |
| No single rescue technique can deal with all technical deployment issues of Hot AXIOS stents. |
| Pre-snaring endoscopic mucosal resection: a simplified alternative to precutting technique for large sessile serrated lesions. |
| Three cases of endoscopic submucosal dissection for vocal fold carcinoma and precancerous lesions. |
| Gastroenterology |
| 3D Micro-CT Imaging Reveals Early Mucosal Remodeling in Individuals with Potential Celiac Disease. |
| A Randomized Trial Assessing Low-volume Bowel Preparation in Inpatients Undergoing Colonoscopy. |
| Low-SAAG, High-Protein Ascites in an Adolescent: A Diagnostic Paradox. |
| Management of Helicobacter pylori-Associated Disease in a Child: Clinical Considerations Beyond a One-Size-Fits-All Approach. |
| Precision xenogenomics: a major milestone in bridging the organ gap. |
| Promoting High-Quality Palliative Care for Minoritized Sexual and Gender Identity Populations With Advanced Liver Disease. |
| Risk of Colorectal Cancer following Colonoscopy in Older Persons. |
| Gastrointest Endosc |
| From Buttress to Breach: Endoscopic Rescue of a Colonic Fistula Caused by a Retained Pledget. |
| Rendezvous Double-Guidewire Technique for Difficult Minor Papilla Cannulation in Incomplete Pancreas Divisum. |
| Gut |
| Atypical diarrhea in an immunocompetent infant. |
| Ergonomics in endoscopy: common mistakes and key principles. |
| Hepatology |
| Metabolic reprogramming of the tumor microenvironment during transarterial therapy: Where no catheter has gone before. |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
|---|
| Editorial: Bile Acids Under Bulevirtide-A Pharmacodynamic Signature, Not a Prognostic Biomarker. Authors' Reply. |
| Editorial: Tenofovir Alafenamide Versus Entecavir for Hepatitis B Surface Antigen Decline-A Step Towards Functional Cure or a Marginal Margin? Authors' Reply. |
| Editorial: The Role of Liver Biopsy in ANA Positive Subjects. Authors' Reply. |
| Editorial: UDCA Dosing in PBC-Between Guideline Adherence and Clinical Reality: Authors' Reply. |
| Letter on 'Altered Pathogen Spectrum of Spontaneous Bacterial Peritonitis in Patients Treated With Proton Pump Inhibitors'. |
| Letter: FIT-Based Triage for Symptomatic Colonoscopy-Diagnostic Yield Is Not the Same as Pathway Safety. Authors' Reply. |
| Letter: From Regional Diagnostic Thresholds to Phenotype-Guided Management in Asian Reflux Disease. |
| Letter: Gastroparesis in Lung Transplantation: Time to Reframe and Standardise Post-Transplant Foregut Motility Evaluation. |
| Letter: Gastroparesis in Lung Transplantation: Time to Reframe and Standardize Post-Transplant Foregut Motility Evaluation: Authors' Reply. |
| Letter: Pharmacotherapy for Alcohol Dependence in Cirrhosis-By Addressing One Issue Do We Create Another? |
| Gastroenterology |
| Chemotherapy-Induced Remodeling Versus Clonal Selection in CD276-Driven Basal-like Chemoresistance in Pancreatic Cancer. |
| ENPP1 as a Risk-Stratification Biomarker to Inform Selective Surveillance in Chronic Pancreatitis. |
| J Hepatol |
| A call for action: The need to quantify the "-itis" in primary sclerosing cholangitis. |
| Genomics-guided therapy in advanced primary liver cancers: a promising yet methodologically challenging landscape. |
| Histopathology matters for imaging and clinical correlations in Primary Sclerosing Cholangitis. |
| Response to: "Establish a streamlined molecular profiling workflow for the clinical management of advanced cholangiocarcinoma". |