102 articles - From Friday May 15 2026 to Friday May 22 2026
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Endoscopy |
|---|
| Endoscopic diagnosis and management of peptic ulcer bleeding: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2026.
Postendoscopy management 18: ESGE suggests that iron therapy be initiated prior to hospital discharge in patients with peptic ulcer bleeding and iron deficiency and/or anemia. Postendoscopy management 19: ESGE suggests that early oral nutrition, within 24 hours following endoscopic hemostasis, be initiated in patients with peptic ulcer bleeding in whom durable hemostasis has been achieved. |
| Gastroenterology |
| AGA Clinical Practice Update on Management of Clostridioides difficile Infection in Inflammatory Bowel Disease: Expert Review.
BEST PRACTICE ADVICE 11: In patients with IBD, clinicians should not advise probiotics for primary or secondary prevention of CDI. BEST PRACTICE ADVICE 12: In patients with IBD and a history of CDI who are receiving systemic antibiotics, clinicians may consider oral vancomycin prophylaxis as secondary prevention. |
| Nonadvanced Adenoma Number and Size as Predictors of Metachronous Advanced Colorectal Neoplasm: Implications for Surveillance Guidelines.
ACN risk increased with NAA count, with the highest risk observed in 5-10 NAAs, while 3-4 NAAs had higher risk than 1-2 NAAs. Small adenomas further elevated risk within count-based groups. Both NAA number and size should be considered when determining surveillance intervals. |
| Gastrointest Endosc |
| American Society for Gastrointestinal Endoscopy Technology Status Evaluation Report: tools for benign pancreaticobiliary dilation.
Technology Status Evaluation Reports are scientific reviews provided solely for educational and informational purposes. They are not rules and should not be construed as establishing a legal standard of care or as encouraging, advocating, requiring, or discouraging any particular treatment or payment for such treatment. |
| Hepatology |
| Definition, diagnosis, and treatment of primary biliary cholangitis - autoimmune hepatitis (PBC-AIH) variant: An international expert delphi consensus.
This Delphi initiative established consensus in a complex, understudied area lacking evidence-based guidelines. The resulting statements offer a basis for prospective studies and standardized clinical protocols, aiming to enhance consistent management of PBC-AIH. |
meta-analyses and systematic reviews
| Endoscopy |
|---|
| Comparative Efficacy and Safety of Endoscopic Treatments for Gastric Varices: A Systematic Review and Network Meta-analysis.
EUS-guided cyanoacrylate injection with or without coils was associated with lower rebleeding rates compared to conventional endoscopic cyanoacrylate injection. However, the certainty of evidence was very low and further RCTs are needed before firm conclusions can be drawn regarding the relative efficacy and safety of these treatments. |
| Stent indwell duration and adverse events in endoscopic ultrasound-guided lumen-apposing metal stent drainage of peripancreatic collections: systematic review and meta-analysis.
In patients undergoing endoscopic ultrasound-guided drainage of PFCs, evidence suggests no significant association between LAMS indwell time and the incidence of AEs. This challenges rigid early removal policies and supports individualized, clinically driven timing, with structured follow-up and risk mitigation. |
| Gastroenterology |
| Fecal microbiota transplantation for symptom improvement in patients with irritable bowel syndrome: systematic review and meta-analysis of randomized controlled trials.
This systematic review suggested there was very low certainty of evidence that FMT improved IBS symptoms. FMT was effective in some subgroup analyses and in the overall per protocol analysis but this needs to be interpreted with caution. |
| Gut |
| Hepatocellular carcinoma attributable to hepatitis B, hepatitis C and other risk factors at global, regional and national levels: an updated systematic review and meta-analysis.
HBV and HCV contribute to approximately three-quarters of the global HCC burden. These data can inform viral hepatitis prevention strategies. Prospero registration number CRD42023397708. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
|---|
| Clinical trial: Efficacy of a Low FODMAP Diet in Paediatric Irritable Bowel Syndrome-A Randomised Crossover Trial With Exploratory Metabolomic Analysis.
In this randomised crossover trial, a LFD improved abdominal pain and symptom severity in children with IBS, with the greatest benefit in those with severe baseline pain. Exploratory faecal and urinary metabolomic analyses identified candidate features associated with non-response, warranting further validation. |
| Epidemiology, Predictors of Antimicrobial Resistance and Empiric Treatment Strategies for Spontaneous Bacterial Peritonitis in Cirrhosis: A Multicentre SBP-INDIA Study.
There is a high burden of MDRO and CRO in ascitic infections among hospitalized patients with cirrhosis, with clinically relevant impact on outcomes. Empiric antibiotic selection should be guided by acquisition setting, illness severity and resistance risk factors, with stewardship oversight. Similar outcomes between NNBA and SBP suggest that microbiological evidence, rather than neutrophil count alone, should guide decisions. |
| Subtype Differences in Major Adverse Liver Outcomes and Cardiovascular Events and Mortality in Steatotic Liver Disease: A UK Biobank Analysis.
In the United Kingdom, ALD exhibited the highest liver, cardiovascular, and mortality risks, while MASLD and MetALD had similar cardiovascular and survival profiles but differed in liver-related risk. |
| Temporal Association Between COVID-19 Vaccination and HBsAg Loss in Chronic Hepatitis B Infection: An Interrupted Time Series Analysis.
HCC incidence showed no significant changes. COVID-19 vaccination was temporally associated with transiently higher HBsAg loss rates in CHB, followed by attenuation, suggesting a potential population-level immunomodulatory effect on HBV dynamics. |
| Am J Gastroenterol |
| Association of colonoscopy with colorectal cancer incidence among persons aged 40-49 years: A nationwide population-based claims cohort study.
Colonoscopy was associated with a 21%-43% lower CRC risk among individuals in their 40s, with the greatest risk difference observed in men in their late 40s. These findings highlight the importance of age and sex-specific screening guidelines. |
| Evolving Concepts of Treatment Targets for PBC: A Global Perspective.
Nine international PBC experts, representing the United States, Canada, Europe, Asia, Africa, and Central/South America, collaborated to formulate opinions about the unanswered questions related to treatment targets in PBC. The result of this expert review is a global perspective on terminology related to the definition of responses to treatment, risk stratification, and treatment targets that can guide clinicians to optimize PBC treatment worldwide. |
| High Rates of Seroprotection for Measles in Pediatric Patients with Inflammatory Bowel Disease.
Children with IBD have high measles seroprotection. A negative commercial result should not be interpreted as lack of seroprotection, highlighting the need for more accurate assays. |
| Microbiome-Directed Therapy for Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Placebo-Controlled Trial of Multi-Strain Probiotic Supplementation.
While 12 weeks of probiotic administration was not associated with relief of fatigue in patients with quiescent IBD, we observed beneficial alterations in the gut microbiome and serum metabolome. ClincialTrials.gov number, NCT03266484. |
| Transcutaneous Auricular Vagal Nerve Stimulation Alleviates Symptoms of Mild Acute Pancreatitis: A Multicenter Randomized Double-blind Sham-controlled Study.
In patients with MAP, taVNS was associated with earlier symptom resolution and potential anti-inflammatory effects with a favorable safety profile ( ClinicalTrial.gov NCT06998784). |
| Clin Gastroenterol Hepatol |
| A TIME DEPENDENT PROGNOSTIC SCORE (HelPSCore) TO PREDICT DISEASE OUTCOMES IN PRIMARY SCLEROSING CHOLANGITIS.
HelPSCore provides a straightforward and reliable tool for short- and long-term PSC prognosis. This enables the identification of high-risk patients who may benefit from intensified monitoring and tailored therapy. |
| Beyond Chronic Stress: Daily Stress Is Associated with Symptoms in Irritable Bowel Syndrome.
Stress and symptoms are closely linked within the same moment, but also prospectively, particularly later in the day among adults with IBS. These findings highlight the dynamic nature of daily stress-symptom relationships and underscore the potential value of within-day stress management interventions for improving symptom control in IBS. |
| Fibrosis progression rate and comparison of paired liver biopsy versus non-invasive tests as surrogate endpoints for clinical trials in MetALD and ALD.
Active alcohol consumption determines fibrosis progression in ALD and MetALD. Non-invasive biomarkers are promising surrogate markers for understanding disease dynamics and monitoring in ALD and MetALD clinical trials. |
| Hepatic Steatosis Is Associated With Increased Cardiovascular Risk Through Adverse Coronary Plaque Composition: Insights from the PROMISE Trial.
Hepatic steatosis was associated with greater NCPB and increased MACE risk, with NCPB accounting for a portion of this association, suggesting a link between hepatic steatosis and vulnerable coronary atherosclerosis. These findings support integrated cardiometabolic risk assessment in patients undergoing coronary CT angiography. |
| Interval positive fecal immunochemical test is associated with post-colonoscopy colorectal cancer in a screening program.
Patients with a positive interval FIT are at increased risk of PCCRC and should be offered repeat colonoscopy. |
| Long-term outcomes of endoscopic submucosal dissection for esophageal squamous high-grade dysplasia and early squamous cell carcinoma in the west: Absolute versus Outside Criteria.
ESD offers excellent procedural outcomes and provides definitive T-staging for oesophageal squamous HGD and ESCC in Western practice. In those meeting AC, the majority are cured and achieve excellent long-term OS. In the non-cured, mostly OC lesions in the elderly and comorbid, ESD provides durable local disease control and facilitates organ-preservation. Thus, ESD should be considered at the forefront of therapeutic consideration. |
| Real-World Effectiveness of Upadacitinib for Perianal Crohn's Disease: A Multi-Center Retrospective Study.
Treatment with UPA was associated with improved fistula outcomes in patients with pCD, with greater effectiveness in those anti-TNF-naïve or with shorter disease duration. |
| Reliability of Hepatic Steatosis Quantification by Controlled Attenuation Parameter in Steatotic Liver Disease.
The MDC of CAP is >57-69 dB/m (>18-25%) and substantially greater in a longitudinal setting and advanced disease. |
| Twenty-Year Trends in Liver Transplantation Among Hepatitis D Virus-Infected Patients in the U.S. and Europe.
Compared with HBV-monoinfected recipients, HBV/HDV recipients were transplanted younger with more advanced liver disease, underscoring the urgent need for HDV-targeted therapies. Despite their worse pre-transplant profile, HDV patients achieve comparable or superior post-transplant survival. |
| Endoscopy |
| Endoscopic retrograde appendicitis therapy plus antibiotics versus antibiotics alone for uncomplicated acute appendicitis with appendicolith: a propensity score-matched cohort.
Findings support ERAT plus antibiotics as the preferred initial NOM strategy in UAA patients with appendicoliths compared with antibiotics alone. |
| Low-dose rectal indomethacin to prevent post-ERCP pancreatitis: results of a large Chinese multicenter randomized noninferiority trial.
For prevention of PEP, 50 mg of indomethacin was noninferior to 100 mg. The prophylactic use of 50 mg of indomethacin can therefore be considered for PEP prevention in the Chinese population. In addition, for people who have a history of pancreatitis, 100 mg of rectal indomethacin may be preferable for prevention of PEP. |
| Percutaneous transhepatic biliary drainage versus endoscopic ultrasound-guided biliary drainage with primary metal stenting for unresectable malignant distal biliary obstruction.
EUS-BD, particularly EU-CDS, might be preferred over PTBD in unresectable MDBO in terms of better clinical success and lower biliary re-intervention rate. |
| Gastroenterology |
| Inflammation-Induced Claudin-2 Upregulation Limits Pancreatitis Development by Enhancing Pancreatic Ductal Transport.
CLDN2 upregulation is a pathophysiological response to inflammation and absence of CLDN2 exacerbates disease severity. Modulating pancreatic ductal CLDN2 function represents a potential therapeutic strategy for pancreatitis. |
| Gastrointest Endosc |
| "Vanishing needle tract" in endoscopic ultrasound-guided tissue acquisition: definition, incidence, and risk factors in a large single-center cohort.
VNT is a relatively common phenomenon occurring predominantly in the clockwise direction. It is more likely to occur in cases of limited maneuverability, as in the duodenal bulb, or multi-point needle contact, as with a Franseen needle. By defining this novel concept of VNT, our study contributes to the standardization of EUS-TA and future improvements in device design. |
| Endoscopic ultrasound-guided coil and glue embolization of gastric varices targeting feeder vessel versus submucosal variceal complex: A pragmatic comparative analysis (with videos).
For EUS-angioembolization of GV, targeting the feeder vessel, when feasible and discernible, over SVC (conventional method) results in significantly lower requirements of coil and glue, with significantly lower reintervention rates, which might translate to a more cost-effective strategy. |
| Feasibility and safety of endoscopic ultrasound-guided gallbladder drainage using an electrocautery-enhanced lumen-apposing metal stent for inoperable acute cholecystitis with Niemeier type II perforation.
Niemeier type II gallbladder perforation with adjacent encapsulated collections may not represent an absolute contraindication to EUS-GBD in patients with AC. |
| Validity Evidence for an Objective Scoring Tool for Endoscopic Tip Control During Snare Tip Soft Coagulation.
A simple, in-vivo, procedure-level score captured during routine STSC provided an objective measure of endoscopic tip control, separating experts from trainees. |
| Gut |
| Blocking MOXD1-derived ACOX1 peroxisome trafficking suppresses metabolic dysfunction-associated steatohepatitis.
This study identifies MOXD1 as a previously unrecognised regulator of hepatic fatty-acid homeostasis and a key driver of MASH pathogenesis. Targeting the MOXD1-ACOX1 axis offers a promising therapeutic strategy for MASH. |
| Endosomal signalling of protease-activated receptor-2 amplifies histamine-induced pain of irritable bowel syndrome.
Background Proteases and histamine, co-secreted by mast cells and bacteria, sensitise colonic nociceptors and contribute to irritable bowel syndrome (IBS) pain. Objective To determine whether irreversible proteolytic cleavage of protease-activated receptor-2 (PAR endosomal signalling makes a dominant contribution to IBS-related colonic pain. |
| MAIT cell enrichment in Lynch syndrome is associated with immune surveillance and colorectal cancer risk.
These findings define key features of the LS colonic microenvironment and suggest that MAIT cell enrichment contributes to immune surveillance against CRC, offering new insights into disease penetrance, risk stratification and prevention. |
| Urgent versus early ERCP in mild-to-moderate acute cholangitis: a randomised controlled trial.
In patients with mild-to-moderate acute cholangitis, urgent ERCP within 24 hours was not superior to early ERCP within 24-48 hours with respect to mortality or organ failure and is associated with a higher rate of procedure-related adverse events. |
| Hepatology |
| CD4+ T cells promote fibrosis during metabolic dysfunction-associated steatohepatitis.
These studies provide a comprehensive single-cell proteogenomic atlas of CD4+ T cells in MASH and identify an OX40-dependent CD4+ T cell-macrophage axis as a promising therapeutic target for the treatment of MASH and liver fibrosis. |
| J Hepatol |
| siRNA JNJ-73763989 decreases HBsAg and HDV RNA in NA-treated hepatitis D patients but may cause ALT flares.
Despite the low sample size and majority of participants not completing the planned treatment course, these findings are important for caregivers and researchers developing novel treatment strategies for patients with CHD. Identifier: NCT04535544. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
|---|
| Editorial: Prevention of Upper GI Bleeding in Users of Anti-Thrombotic Drugs-P-CABs Versus PPIs. |
| Editorial: Silent But Detectable-High-Throughput Proteomics to Identify Clinically Significant Liver Disease. |
| Editorial: Tenofovir Alafenamide Versus Entecavir for Hepatitis B Surface Antigen Decline-A Step Toward Functional Cure or a Marginal Margin? |
| Editorial: Two Common Risks, One Greater Harm-Diabetes and Alcohol in Steatotic Liver Disease. |
| Gastrointest Endosc |
| A note from the Editor-in-Chief. |
| Addressing behavior, physiology, and anatomy in the treatment of patients with weight regain after sleeve gastrectomy. |
| Closure of gastrointestinal fistulas: refining current endoscopic techniques. |
| Expanding endoscopic ultrasound boundaries: Is there a role for endoscopic ultrasound-guided ethanol lavage in renal cyst treatment? |
| Gastric indefinite for dysplasia: from diagnostic uncertainty to risk-stratified management. |
| Multipoint traction during colorectal endoscopic submucosal dissection: Is more traction always the answer? |
| Sustainability in endoscopy: What is your WEN (waste in endoscopy number)? |
| Sustained disease control after cryoballoon ablation for neoplastic Barrett's esophagus: insights from long-term follow-up. |
| The role of nudges in studies comparing drugs with empiric dosing. |
| Twenty-first century challenges in the delivery of bad news. |
| J Hepatol |
| A call for sharing individual patient data from trials in hepatology.
To succeed, IPD must be shared with other researchers. Here we present the history of IPD sharing, the past and current proportions of hepatology trials stating their willingness to share IPD, and our own experience with reuse of IPD data from hepatology trials. |
| The role of liver sinusoidal endothelial cells in liver diseases: Key players in health and pathology.
Despite innovative tools supporting the dissection of LSEC heterogeneity, our understanding of LSEC pathobiology remains limited and characterised by important gaps. This review highlights recent discoveries and examines possible innovative therapeutic strategies targeting LSECs in liver disease. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| Enterolithiasis in a Long-term Magnesium Oxide User. |
| Non-Hepatic Cancer in Patients with Liver Cirrhosis: Epidemiology, Treatment Challenges, and Management Strategies. |
| Squamous Cell Carcinoma of the Bladder Invading the Sigmoid Colon in the Setting of Chronic Schistosomiasis. |
| Clin Gastroenterol Hepatol |
| GIVersa-Endoscopy: A Large Language Model-Based AI Assistant for Endoscopy Sedation Triage. |
| Optimizing Histologic Entry Criteria for Clinical Trials in Celiac Disease Involving Gluten Challenge. |
| Endoscopy |
| A novel endoscopic ultrasound system assisted by artificial intelligence for the recognition of pancreatic parenchyma and the detection of solid/cystic lesions. |
| A novel flexible endoscopic C-shaped suturing device for colonic wound closure in a porcine model. |
| Application of a novel peaked transparent cap to assist in rectal endoscopic submucosal dissection. |
| Beyond cleansing adequacy: work and patient-reported outcomes in bowel-preparation trials. |
| Beyond glue injection: rethinking strategy in gastric variceal bleeding. |
| Can artificial intelligence fulfill its potential to improve health and reduce costs? |
| Effective robotic arm-assisted traction for endoscopic submucosal dissection treating ulcerative colitis-associated colonic neoplasia. |
| Endoscope-assisted single-port intragastric surgery for gastric submucosal tumors in the fornix. |
| Endoscopic removal using perioral cholangioscopy for biliary migration of vascular coil placed to treat biliary tract bleeding caused by ruptured right hepatic artery aneurysm. |
| Endoscopic retrieval of an N-butyl-2-cyanoacrylate cast from the common bile duct: a rare complication of portal vein embolization. |
| Endoscopy E-Videos - recently published. |
| From local to systemic: endoscopic findings reshape the diagnostic paradigm of satoyoshi syndrome - a case report. |
| Gallbladder perforation during peroral holmium laser lithotripsy. |
| Half-release and full aspiration technique for endoscopic ultrasound-guided hepaticogastrostomy in severe acute cholangitis. |
| Muscle-clipping suturing for closure of a gastric defect after endoscopic submucosal dissection for a type 3 neuroendocrine neoplasm. |
| No single rescue technique can deal with all technical deployment issues of Hot AXIOS stents. |
| Pre-snaring endoscopic mucosal resection: a simplified alternative to precutting technique for large sessile serrated lesions. |
| Retrograde-antegrade rendezvous recanalization for complete cervical esophageal obstruction after chemoradiotherapy: a novel organ-preserving approach. |
| Successful pocket creation method using a multimodal device in endoscopic submucosal dissection for a colonic lateral spreading tumor. |
| Gastroenterology |
| Multiple Pancreatic Masses in a Young Woman: What Are We Really Treating? |
| Gastrointest Endosc |
| From Buttress to Breach: Endoscopic Rescue of a Colonic Fistula Caused by a Retained Pledget. |
| Rendezvous Double-Guidewire Technique for Difficult Minor Papilla Cannulation in Incomplete Pancreas Divisum. |
| Ultra-acute-onset arytenoid congestion during esophagogastroduodenoscopy. |
| Gut |
| 12-HETE: a novel lipid mediator of CD8<sup>+</sup> T cell dysfunction in MASH/HCC. |
| Atypical diarrhea in an immunocompetent infant. |
| Hepatology |
| Consistent efficacy of efruxifermin across PNPLA3 genotypes in phase 2b trials in MASH. |
| J Hepatol |
| From the Editor's Desk... |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
|---|
| Editorial: Refining the Natural History of MASLD by Imaging-Based Markers: The GOLDMINE Study. Authors' Reply. |
| Editorial: The Milan Score as Supportive Evidence of Gastro-Oesophageal Reflux Disease. Authors' Reply. |
| Letter: Disease Stage and Absolute Risk in Evaluating the Branched-Chain Amino Acid to Tyrosine Ratio in Cirrhosis. |
| Letter: Disease Stage and Absolute Risk in Evaluating the Branched-Chain Amino Acid to Tyrosine Ratio in Cirrhosis. Authors' Reply. |
| Letter: FIT-Based Triage for Symptomatic Colonoscopy-Diagnostic Yield Is Not the Same as Pathway Safety. |
| Letter: Peripheral Eosinophilia Does Not Correlate With Endoscopic and Histological Activity in Paediatric Eosinophilic Oesophagitis. |
| Letter: Therapeutic Targeting of PPARs in PBC-Additional Considerations. |
| Letter: Unmasking the Risks-The Need for Robust Data on Baclofen in Cirrhotic Patients. Authors' Reply. |
| Clin Gastroenterol Hepatol |
| Timing of DOAC resumption after colonoscopy: caution against overinterpreting bleeding safety. |
| Gastroenterology |
| Bridging Genetics and Bedside Decisions in IBD: Utility Metrics for Susceptibility PGS. |
| Gastrointest Endosc |
| Contrast-enhanced endoscopic ultrasound: it is not all in the diagnostic accuracy. |
| Refinement at a cost: technical innovation should not eclipse safety considerations. |
| Unequal yardsticks: detection bias in fluoroscopy-free cholangioscopy trials. |