34 articles - From Friday May 01 2026 to Friday May 08 2026
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Clin Gastroenterol Hepatol |
|---|
| AGA Clinical Practice Update on Diagnosis and Treatment of Hemorrhoids: Expert Review.
For most clinicians, significant coagulopathy means a platelet count of less than 50,000 per microliter or INR greater than 2.0. The presence of concomitant portal hypertension should not alter this approach. |
| Gastroenterology |
| Recommendations for the Evaluation and Management of Inflammatory Bowel Disease with Irritable Bowel Syndrome-Like Symptoms: A Joint Rome Foundation and International Organization for the Study of IBD (IOIBD) Consensus.
Appropriate therapies included psyllium (if no stricture), a short-term low FODMAP diet, targeted drugs, and brain-gut behavioral therapies. This first joint consensus provides standardized terminology, evaluation strategies, and treatment recommendations for IBD with IBS-like symptoms, supporting improved clinical management and guiding future mechanistic and therapeutic research. |
meta-analyses and systematic reviews
RCT, clinical trials, retrospective studies, etc…
| Am J Gastroenterol |
|---|
| Efficacy and Safety of Guselkumab for Ulcerative Colitis Through Week 92 of the QUASAR Long-Term Extension Study.
Sustained and durable corticosteroid-free efficacy and safety were observed among participants receiving up to 2 years of guselkumab maintenance treatment. |
| Clin Gastroenterol Hepatol |
| Antibiotic use and later risk of celiac disease: A nationwide case-control and sibling analysis.
Individuals with CD were more often exposed to antibiotics before diagnosis than their general population comparators. However, an even stronger association with antibiotic use was seen in those with normal mucosa, suggesting that heightened surveillance rather than causality may contribute to the observed patterns. Although antibiotic stewardship remains important, CD concerns should not deter appropriate antibiotic use. |
| Impact of stopping thiopurines under anti-TNF therapy in inflammatory bowel disease: A population-based study.
Discontinuing thiopurines after initiating anti-TNF therapy was associated with a modest increase in the risk of adverse clinical events in patients with UC. This warrants careful risk-benefit assessment before stopping thiopurines after escalation to anti-TNF therapy. |
| Gastroenterology |
| Bioengineering a probiotic to bloom during colonic inflammation promotes reliable efficacy in translational models of colitis.
We provide a proof-of concept study that bioengineering ttr into EcN unlocks a robust therapeutic effect during colitis. EcN::ttr may be a novel microbiome therapeutic for IBD due to its enhanced ability to successfully colonize the inflamed gut. |
| Hepatology |
| BMN 349, a small molecule inhibitor of Z alpha-1 antitrypsin polymerization, increases secretion and reduces intrahepatic inclusions in a mouse model of disease.
This study is the first to demonstrate a reduction in Z-AAT polymer burden without altering protein expression. Improvements in liver inflammation and function following BMN 349 treatment support further investigations of its therapeutic benefits for AATD liver disease. |
| Combined HDV RNA and Anti-HDV measurement for the management of HBV/HDV coinfection.
Combined HDV RNA and anti-HDV quantification provides complementary information for characterizing HBV/HDV infection and monitoring treatment response. Declining anti-HDV levels associate with virological control. These results prompt prospective multicentre studies of their role in the clinical and therapeutic management of patients with HBV/HDV coinfection. |
| Efficacy and safety of belapectin for the prevention of esophageal varices in patients with MASH cirrhosis: The randomized, placebo-controlled NAVIGATE trial.
Belapectin 2 mg/kg lowered development of new varices in MASH cirrhosis and portal hypertension. Registered at clinicaltrialsgov NCT04365868. |
| FIB-4 fails to identify significant liver fibrosis in people with HIV: A large multinational screening study.
In PWH, liver fibrosis is common and frequently missed by FIB-4, particularly in MASLD. TE-centered screening strategies augmented by metabolic and HIV-specific indicators may improve early fibrosis detection and risk stratification. |
| The linoleic acid-derived leukotoxin 9,10-DiHOME drives immunosuppression in patients with acute-on-chronic liver failure.
These findings indicate that increased levels of the leukotoxin 9,10-DiHOME weakens immune-cell defensive responses and position sEH as a potential drug target in ADC. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Clin Gastroenterol Hepatol |
|---|
| When Pharmacology Meets Expectancy: Lessons From Two Negative Trials in Disorders of Gut-Brain Interaction. |
| Gastroenterology |
| Optimal Timing of Endoscopic Necrosectomy in Patients with Symptomatic Necrotizing Pancreatitis following Catheter Drainage: Still Wondering. |
| J Hepatol |
| Anti-TNF therapies in autoimmune hepatitis: promises and challenges. |
| Editorial:Professor Florence Wong - A career of scientific excellence, mentorship and lasting impact. |
| From science to public health impact: enacting the recommendations of the EASL-Lancet Commission on liver health in Europe. |
| Global biliary tract cancer genomics: from geographic patterns toward biological subtypes. |
| Harnessing the oral microbiome in chronic liver disease: mechanisms, therapeutic modulation and translational frontiers.
Integrating oral health into hepatology practice may represent a practical opportunity to reduce infection risk, delay decompensation, and improve survival and quality of life in people living with ACLD. This review aims to synthesise concepts around current understanding of the patho-biological mechanisms, analytical innovations, and therapeutic opportunities that define this evolving connection, as well as identify gaps in the knowledge base and propose avenues to harness and exploit the oral-gut-liver axis. |
| Scoring breakthroughs at Villa Park: David Adams and the science of rolling liver lymphocytes. |
| Uncovering immune dysfunction in ACLF: cellular mechanisms, molecular pathways, and therapeutic frontiers.
The review expands on immune cell communication within the immune system (innate and adaptive), with other non-parenchymal and parenchymal cells and at the inter-organ level, detailing interactions between immune cells of key organs and compartments affected during ACLF, including the liver, circulation, brain, gut and kidney. Finally, we summarize the latest preclinical and clinical findings exploring biomarkers of immune dysfunction and immunomodulatory therapeutic strategies aimed at restoring immune homeostasis in patients with ACLF. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| Management of Bleeding Gastric Varices: A practical approach to an impractical problem. |
| Clin Gastroenterol Hepatol |
| Schatzki's Rings: Recognition, Significance, and Management. |
| Endoscopy |
| Combined endoscopic salvage: pancreatoscopy and endoscopic ultrasound-guided pancreatic duct drainage for synchronous postoperative pancreatic fistulas. |
| Endoscopic ultrasound-guided balloon dilation plus platelet-rich plasma for fibrotic ileocecal stricture in Crohn's disease. |
| When endoscopic full-thickness resection goes wrong: strategy for resolution. |
| Gastroenterology |
| A Young Man with Refractory Esophageal Stricture. |
Letters to the editors and authors’ replies
| Gastroenterology |
|---|
| Biomarker Combinations and Novel Surveillance Strategies: A "Traffic Light" Approach and Resource Optimization. |
| Not So Fast, My Friend: Biomarkers May Play an Important Role in HCC Surveillance. |
| Optimizing the Evaluation of Biomarkers for HCC Surveillance. |
| Toward Precision HCC Surveillance: Standardizing Ultrasound Visualization and Optimizing Biomarker Integration. |
| J Hepatol |
| Beyond steroid-dependent care: can TNF blockade evolve into a precision therapy for autoimmune hepatitis? |
| Circulating FGF21 levels reflect liver disease risk and metabolic stress in the UK Biobank. |
| IFRD1: a promising target in human liver regeneration. |
| Letter in response to Hepatic CTSB is Kupffer cell-enriched, whereas disease-state stratification is more strongly captured by endotoxin/TLR4 programmes. |