107 articles - From Friday Mar 06 2026 to Friday Mar 13 2026
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Gastrointest Endosc |
|---|
| A path forward: underrepresented in medicine-gastroenterology. |
| A path forward: women in gastroenterology. |
meta-analyses and systematic reviews
| Gastrointest Endosc |
|---|
| EFFICACY AND SAFETY OF ENDOSCOPIC ULTRASOUND-GUIDED CHOLEDOCHODUODENOSTOMY COMPARED WITH ENDOSCOPIC ULTRASOUND-GUIDED GALLBLADDER DRAINAGE FOR PALLIATION OF MALIGNANT DISTAL BILIARY OBSTRUCTION: A SYSTEMATIC REVIEW AND META ANALYSIS.
EUS-GBD appears comparable to EUS-CDS in terms of technical and clinical success, adverse events, and stent dysfunction. Further prospective studies are warranted to corroborate our findings. |
| Upfront Endoscopic Necrosectomy Versus Step-Up Endoscopic Approach for Walled-off Pancreatic Necrosis: A systematic review and meta-analysis.
Our study demonstrates that UEN and SUEN perform similarly in terms of commonly measured efficacy and safety endpoints. This finding underscores the importance of individualized approach in the treatment of patients with walled-off pancreatic necrosis. |
| J Neurogastroenterol Motil |
| Clinical Guidance and Practical Recommendations for Probiotic Use in Patients With Irritable Bowel Syndrome, Functional Constipation, and <i>Clostridium difficile</i> Infection Considering Sex-based Differences.
In conclusion, probiotics might play a role as adjunctive therapy for IBS and FC, with variability in responses influenced by microbial, host, and potential sex-related factors. Further research is needed to establish optimized personalized probiotic strategies. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
|---|
| Effects of a Personalised FODMAP Diet Versus the National Institute for Health and Care Excellence (NICE) Dietary Advice on Symptom Control in Patients With Irritable Bowel Syndrome: Randomised Clinical Trial.
An individualised, less restrictive personalised FODMAP diet yields symptom improvement comparable to NICE dietary advice while preserving nutritional adequacy. Personalised dietary strategies may enhance feasibility and long-term adherence in IBS management. |
| Frailty Is Associated With All-Cause and Acute Hospitalisations During 18 Months Follow-Up in Older Patients With Inflammatory Bowel Disease.
Frailty, reflected by severe deficits in geriatric assessment, is independently associated with all-cause and acute hospitalisations in older patients with IBD. |
| Post-Operative Recurrence of Colonic Crohn's Disease After Colectomy: The RESECOL Study by the Young Group of GETECCU.
Clinical and endoscopic POR rates are significantly lower following SC compared with STC in colonic CD, while radiologic and surgical recurrence rates were similar. SC shows a protective effect regarding clinical and early endoscopic POR. These data support segmental resection of colonic CD when feasible. |
| Real-World Alcohol Use Disorder Outcomes in Patients With Concurrent Metabolic Dysfunction: GLP-1 Receptor Agonists Versus FDA-Approved AUD Medications.
GLP-1RAs are a promising option for patients with concurrent MetD and AUD, improving relapse rates and metabolic outcomes compared with currently FDA-approved pharmacotherapies for AUD. Trends toward better liver outcomes support further prospective evaluation. |
| Am J Gastroenterol |
| Long-term Infant Outcomes After In Utero Biologic Exposure: Results from the Pregnancy Inflammatory Disease Neonatal Outcomes (PIANO) Registry.
These findings support the use of effective IBD therapies throughout pregnancy. |
| Clin Gastroenterol Hepatol |
| Mirikizumab Long-Term Efficacy and Safety in Patients with Crohn's disease: Results from the VIVID-2 Open-Label Extension Trial.
Long-term treatment with mirikizumab for up to 104 weeks was associated with durable improvements in patients with CD. Over 30% of endoscopic non-responders at 1 year achieved endoscopic response with mirikizumab reinduction. Safety was consistent with the known mirikizumab safety profile. ID no NCT04232553. |
| Gastroenterology |
| A Gut-Restricted Liver X Receptor Agonist Ameliorates Liver Injury in Experimental Short Bowel Syndrome.
These data underscore the potential of gut-restricted LXR agonists to preserve metabolic health in the context of SBS. By acting locally in the intestine, WUSTL0717 positively mitigates profibrotic liver injury while avoiding systemic availability. |
| Cardiovascular Outcomes following Major Gastrointestinal Bleeding in Patients with Pre-existing Cardiovascular Disease: the INTERBLEED International Prospective Cohort Study.
GIB in patients with CV disease is independently associated with subsequent morbidity and mortality. Patterns in antithrombotic resumption were associated with outcomes. Further research into optimal antithrombotic management following GIB is essential. |
| Clinical Care Pathway for the Risk Stratification and Management of Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease.
This paper describes updates to the MASLD Clinical Care Pathway based on the best available evidence and adds an implementation framework based on established implementation theories and models applicable to MASLD. This updated pathway is intended to be applicable in any setting providing care for patients with MASLD, including primary care, diabetology/endocrinology, cardiology, obesity medicine, and gastroenterology/hepatology practices. |
| Darvadstrocel in Patients With Crohn's Disease With Complex Perianal Fistulas: The ADMIRE CD II Phase 3 Randomized Trial.
ADMIRE CD II did not meet its primary endpoint of combined remission at week 24, with no statistically significant difference between darvadstrocel and placebo. No new safety signals were identified for darvadstrocel. , Number NCT002209456. |
| Effect of a Computer-Aided Device for Detecting Gastric Neoplasms: A Multicenter, Randomized Controlled Trial.
AI did not improve the detection rate of gastric neoplasms. Further real-world studies are needed to fully address the adaptability of AI. (Chinese Clinical Trial Registry, ChiCTR2100054449.). |
| Perturbations of Diet and Gut Signatures Persist During Remission in Crohn's Disease Despite Effective Immune Suppression.
Perturbations in dietary, ileal, microbial, and metabolic signatures persist during CD remission despite advanced, effective immune treatments. These findings likely underline the remitting-relapsing nature of CD and suggest that interventions targeting diet, epithelial health, and microbial and metabolic functions may promote deeper, longer-lasting remission states. |
| Prevalence and Consequences of APC Mosaicism in Patients With Colorectal Adenomas.
We recommend APC mosaicism testing at least in patients negative for germline pathogenic variants with (1) ≥20 adenomas before the age of 60 or (2) ≥30 adenomas before the age of 70. Regular colonoscopy and at least 1 gastroduodenoscopy should be offered to APC mosaic patients, with frequency of follow-up based on findings. Offering germline testing for offspring should be considered. |
| Revealing the Antagonistic Interactions of Faecalibacterium prausnitzii and Bacteroides fragilis in Colorectal Cancer.
Our research characterized a representative microbe-metabolite-host regulatory pathway occurring in CRC, namely the F prausnitzii-PIA-TCERG1/CKAP2 axis antagonizing enterotoxigenic B fragilis-induced CRC progression. As a treatment option, we highlight the therapeutic potential inherent in a tryptophan-rich diet and in manipulating microbial composition targeting the F prausnitzii-PIA axis to prevent CRC. |
| Gastrointest Endosc |
| Endoscopic Gastric Remodeling and Its Histologic Impact on Metabolic Dysfunction-associated Steatohepatitis: A 12-month Prospective Study.
EGR improves histologic MASH and fibrosis and represents a promising minimally invasive therapy. |
| Evaluating the Impact of Different Biliary Stents for Bile Leak Following Fenestrated Cholecystectomy: A Retrospective Multicenter Study.
This is the largest cohort studied in this population. There was no significant difference in PCBL healing irrespective of stent type, diameter, length, or positioning relative to the cystic duct. This challenges the belief that a leak from a large fenestrated gallbladder opening requires a large diameter stent or coverage of the CD. Plastic stents can be effectively used in bile leaks following FC and provide significant cost benefits. |
| Use of a screw dilator for pancreaticobiliary disease.
This first U.S. experience demonstrates that the Tornus ES screw dilator is an effective salvage tool during therapeutic EUS and ERCP for pancreaticobiliary disease. |
| Gut |
| <i>Roseburia inulinivorans</i> increases muscle strength.
Results The relative abundance of emerges as a species-specific modulator of muscle strength, linking gut microbiota to muscle metabolism and function. These findings support its potential as a probiotic candidate for nutraceutical interventions targeting age-related muscle-wasting diseases. |
| Gut microbiome signatures in colorectal neoplasia: a cross-sectional study across neoplasia stages and subtypes.
This large prospective cross-sectional study found weak and inconsistent associations between the gut microbiome and premalignant colorectal neoplasia, with no robust microbial signatures. Findings suggest that previously reported microbial shifts may emerge later in disease progression, potentially as a consequence rather than a cause of CRC. Longitudinal, multiomic studies disentangling temporal and causal pathways between the gut microbiome and neoplasia are required. |
| High versus gradually increasing energy nutrition in the early phase of acute pancreatitis (GOULASH): a multicentre double-blind randomised clinical trial.
Based on this early terminated trial, a high-energy strategy for early nutrition in pancreatitis does not decrease mortality/severity, but potentially increases organ failure and pain relapse rate. |
| Novel insights into autoimmune gastritis: clinical profile and gastric neoplastic risk from an international multicentre study.
AIG presentation and neoplastic risks differ by region, warranting further research and potentially region-specific follow-up strategies. |
| Nucleotide analogue bemnifosbuvir inhibits hepatitis E virus replication in preclinical models.
Given BEM's favourable safety profile in preclinical and clinical settings, our results suggest investigating its efficacy in patients with chronic HEV infection. |
| SLC6A14-mediated carnitine transmembrane uptake from PPARγ<sup>+</sup> cancer-associated fibroblasts promotes recurrence of pancreatic cancer.
PC cells exploit carnitine secreted by PPARγ + CAFs via SLC6A14-mediated uptake to promote tumour recurrence. Targeting the CSS, particularly in combination with chemotherapy or immunotherapy, represents a promising avenue for mitigating recurrence in PC. |
| Hepatology |
| Aspartyl-tRNA synthetase 1 (DARS1) reshapes hepatocellular carcinoma proteome and promotes aggressiveness through non-canonical SAGA-MYC signalling modulation.
DARS1 is frequently overexpressed in HCC and detectable in plasma, supporting its potential as liquid biopsy biomarker. Functionally, DARS1 represents a novel vulnerability of HCC, acting through both proteome reshaping and non-canonical nuclear interactions with the SAGA complex that modulate MYC activity. |
| FYN/LCK kinase balance as a metabolic switch orchestrates progenitor exhausted T Cell differentiation in hepatocellular carcinoma.
This study establishes the balance between SRC kinases FYN and LCK as a critical regulator of the terminal exhaustion of Tpex cell through metabolic reprogramming. The finding suggests that modulating the FYN/LCK kinase balance is a promising strategy to overcome immunotherapy resistance in HCC. |
| Hepatocyte CEBPA-ORM1 axis restricts alcohol-associated liver disease.
These findings identify the hepatocyte CEBPA-ORM1 axis as a critical suppressor of ALD, offering therapeutic targets and nominating serum ORM1 as a potential biomarker for staging ALD severity. |
| Original research: Amplification of genetic and metabolic factors in alpha-1 antitrypsin deficiency.
Our data demonstrate the interaction between genetic and metabolic risk factors in AATD and provide evidence for patient management. |
| T and B cell targeting DNA/MVA HCV vaccines induce strong and broad cellular and humoral immunity in mice and rhesus macaques.
These findings show that the DNA/MVA prime/boost vaccination induces a strong and broad CD4 and CD8 T cell response to multiple HCV proteins and a neutralizing antibody response. These results aid in the development of vaccines for HCV. |
| J Hepatol |
| Distinct molecular pathways regulated by activated AKT and YAP signaling during intrahepatic cholangiocarcinoma progression: Roles of AKT and YAP during iCCA.
We characterize distinct molecular signatures of AKT and YAP in iCCA progression and identify YAP as a key regulator of the tumor immune microenvironment (TIME). Our findings support combining YAP inhibition with immune checkpoint inhibitors (ICIs) for iCCA treatment. Impact and implications Our studies elucidate the distinct contributions of AKT and YAP signaling to iCCA progression. Using innovative doxycycline-inducible models, we demonstrate that while both pathways regulate tumor cell proliferation, with YAP doing so by repressing the tumor suppressor RNF125, AKT primarily governs metabolism whereas YAP controls differentiation and suppresses the immune microenvironment. Importantly, YAP inhibition reshapes the tumor immune landscape, and its combination with PD-L1 blockade induces profound tumor regression. These findings establish YAP as a key regulator of the iCCA immune microenvironment and provide a strong preclinical rationale for combining YAP pathway inhibition with immune checkpoint inhibitors for iCCA treatment. |
| Kupffer cell plasticity regulates hepatic immunity in mycobacterial infection: Kupffer cell plasticity.
Mycobacterial infections unmask KCs as highly plastic cells, critical to responding to extreme environmental changes. Impact and implications KCs are traditionally regarded as terminally differentiated macrophages with limited plasticity, reliant on monocyte-derived KCs during liver infections or injury. In contrast, using a chronic mycobacterial infection model, we found tissue-resident KCs to be very plastic cells, which are strongly engaged in the antimycobacterial response and adopt a specific spatial distribution. These findings suggest that KC respond with a unique and organ-specific program to chronic mycobacterial infections. |
| Tissue-specific regulation of PNPLA3 promotes lipid remodeling in response to dietary and environmental challenges: Tissue-specific PNPLA3 lipid remodeling.
These findings reveal striking tissue- and context-specific regulation of PNPLA3, but a conserved association between its expression and TG-LCPUFAs levels, suggesting that PNPLA3 modulates lipid remodeling in response to metabolic stress and that disrupting this function may contribute to SLD susceptibility. Impact and implications Despite being the strongest genetic risk factor for SLD, PNPLA3's physiological role remains unclear. Using mouse models, this study reveals that PNPLA3 is regulated in a tissue-specific manner in response to feeding and cold exposure, thereby promoting remodeling of cellular lipids to adapt to dietary and environmental challenges. The localization of PNPLA3 action and its tissue-specific regulation are directly relevant to hepatologists and metabolic researchers aiming to understand its influence on intracellular lipid composition and its effects on disease susceptibility. Moreover, modulation of PNPLA3 turnover-and its impact on LCPUFAs remodeling-emerges as a potential therapeutic strategy for regulating lipid homeostasis in SLD. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
|---|
| Editorial: Genotyping for Hepatocellular Carcinoma Risk Stratification in the General Population. |
| Editorial: Immune Checkpoint Inhibitors in Hepatocellular Carcinoma Prior to Liver Transplantation-Current Evidence and Future Directions. |
| Editorial: Proton Pump Inhibitors and the Changing Face of Spontaneous Bacterial Peritonitis. |
| Clin Gastroenterol Hepatol |
| Mentorship in Gastroenterology - The Final Lesson. |
| Gastroenterology |
| From Old Battles Won to New Frontiers in Familial Adenomatous Polyposis. |
| In Memoriam: Eugene P. DiMagno, MD. |
| Our New President-Byron L. Cryer, MD, AGAF. |
| J Hepatol |
| BCLC classification and AI-based image quantification: What is meant to be will come together - but how and when?: BCLC and AI-based image quantification.
While challenges related to technical, administrative, and cost-related, but also training-related factors have to be taken into account, a certain aversion to change, as well as absence of standardized AI validation and missing workflow integration hamper the clinical implementation in routine care. This article aims to evaluate current AI-quantified imaging parameters and their potential for synergy with the established BCLC classification. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| A Cautionary Note in the Era of Computer Aided Detection of Polyps at Colonoscopy and Need for Human Centered Design. |
| A Continuous Metallic Stream: Endoscopic Salvage of Migrated Hepatic Artery Coils. |
| Calendar of Courses, Symposiums and Conferences. |
| Ciliated Hepatic Foregut Cyst with Clustered Echogenic Foci: An Incidental Finding on Health Screening. |
| Correction to Higher Rate of Spontaneous Bacterial Peritonitis Recurrence With Secondary Spontaneous Bacterial Peritonitis Prophylaxis Compared With No Prophylaxis in 2 National Cirrhosis Cohorts. |
| SURGICAL HEMORRHOIDECTOMY UNEXPECTEDLY RESULTING IN DIAGNOSIS OF MUCOSAL MELANOMA. |
| Clin Gastroenterol Hepatol |
| Development and Implementation of an Endoscopic Submucosal Dissection (ESD) Program. |
| Endoscopy |
| A multimodal endoscopic approach to early cardiac cancer in gastritis cystica profunda. |
| Bridging multi-hole self-expandable metal stent deployment for hepatic hilar obstruction under endoscopic ultrasound guidance. |
| Cholangioscopy-assisted endoscopic ultrasound-guided gastroenterostomy. |
| Contrast-enhanced endoscopic ultrasound-guided additional ethanol ablation after early detection of occult residual pancreatic insulinoma. |
| Conversion from vertical to tangential view using the anchor traction method in colorectal endoscopic submucosal dissection. |
| Diagnostic and therapeutic role of cholangioscopy in pancreaticoduodenal fistula. |
| Elongated flap combined with pulley-traction method for the treatment of early duodenal bulb adenocarcinoma. |
| Endoscopic full-thickness resection of a rectal submucosal tumor with the double-tunnel bridge formation method: a case report. |
| Endoscopic fully covered self-expanding metallic stent placement combined with a novel over the-scope clip for the closure of a complex esophagomediastinal fistula. |
| Endoscopic gallbladder-preserving cholecystolithotomy via a combined percutaneous and endoscopic ultrasound-guided approach. |
| Endoscopic resection of a giant long-pedunculated Brunner's gland hyperplasia in the duodenum. |
| Endoscopic retrieval of a displaced nasocystic catheter from a pancreatic pseudocyst cavity following initial endoscopic ultrasound-guided drainage. |
| Endoscopic submucosal dissection is a safe and effective method for the treatment of duodenal papillary neuroendocrine tumor involving the pancreatic duct orifice. |
| Endoscopic ultrasound-guided injection-assisted precise localization for endoscopic removal of a penetrating foreign body in the gastric antrum: a case report. |
| Endoscopic ultrasound-guided treatment for non-stenotic cholangitis in transplant recipient with hepaticojejunal anastomosis. |
| Post-pancreatectomy clip migration: a two-stage management approach with pancreatography and pancreatoscopy. |
| Safe retrieval of gastrointestinal foreign bodies using the novel endoscopic attachment with a flower-shaped design. |
| Segment-targeted peroral endoscopic myotomy for recurrent diffuse esophageal spasm with giant diverticula. |
| Successful simultaneous side by side placement of novel 6-Fr inside plastic stents for malignant hilar biliary obstruction. |
| The retained-bridge traction strategy: a novel solution for secure defect closure following duodenal endoscopic full-thickness resection. |
| The usefulness of the novel 0.018-inch dedicated uneven double-lumen cannula for endoscopic ultrasound-guided hepaticogastrostomy using a 22-gauge needle. |
| Ultrathin endoscope-assisted endotracheal intubation in the prone position for endoscopic retrograde cholangiopancreatography: a standardized protocol. |
| Gastroenterology |
| Association Between Ultraprocessed Food Intake and Inflammatory Bowel Disease Risk: A Propensity-Matched Analysis With Monte Carlo Simulation From the Prospective Urban Rural Epidemiology Study. |
| Clinical Validation of a Simulation-Based Mastery Learning Curriculum for Colonoscopy and Polypectomy in Practicing Gastroenterologists. |
| Gastric Peroral Endoscopic Pyloromyotomy (G-POEM) Is Effective in the Treatment of Diabetic Gastroparesis: A Randomized, Double-Blinded, Sham-Controlled Trial. |
| Gastrointest Endosc |
| Clip-with-line-assisted endoloop ligation and snare resection for a giant pedunculated ileal adenoma. |
| Energizing Endoscopic Sutured Marginal Ulcer Repair. |
| First Report of Recurrent Hemobilia Induced by Pembrolizumab: Endoscopic Findings and Management. |
| Retrieving a Misdeployed Lumen Apposing Metal Stent Using a Large Channel Scope. |
| Underwater Small-Bowel Endoscopic Stricturotomy for Crohn's Disease-Associated Small-Bowel Strictures (with video). |
| Gut |
| Appearances can be deceiving: an ulcerated oesophageal lesion. |
| Parental obesity imprints offspring risk for MASLD: act now to protect future generations. |
| Post-infection disorders of the gut: of latitude and longitude. |
| Steatosis severity and metabolic fingerprints after HCV eradication: toward an individualised approach to HCC surveillance after HCV cure. |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
|---|
| Editorial: Genotyping for Hepatocellular Carcinoma Risk Stratification in the General Population. Authors' Reply. |
| Editorial: Immune Checkpoint Inhibitors in Hepatocellular Carcinoma Prior to Liver Transplantation-Current Evidence and Future Directions. Authors' reply. |
| Letter: Double-Dose Hepatitis B Vaccination in IBD-A Step Forward in Protecting Immunosuppressed Patients. |
| Letter: Double-Dose Hepatitis B Vaccination in IBD-A Step Forward in Protecting Immunosuppressed Patients. Authors' Reply. |
| Letter: Eating Disorders in Inflammatory Bowel Disease-Are We Asking the Right Questions? |
| Letter: Improving the Interpretability and Portability of Tumour Burden Score-Based Prediction of Extrahepatic Progression After Transarterial Chemoembolisation (TACE)-Author's Reply. |
| Letter: Improving the Interpretability and Portability of Tumour Burden Score-Based Prediction of Extrahepatic Progression After Transarterial Chemoembolization (TACE). |
| Letter: Liver Transplantation Outcomes for Alcohol-Associated Liver Disease-Commentary on an Individual Patient Data Meta-Analysis and Future Research Directions. |
| Letter: Liver Transplantation Outcomes for Alcohol-Associated Liver Disease-Commentary on an Individual Patient Data Meta-Analysis and Future Research Directions. Authors' Reply. |
| Letter: Methodological Considerations in Interpreting Polygenic Risk Scores for Hepatocellular Carcinoma After SVR. |
| Letter: Methodological Considerations in Interpreting Polygenic Risk Scores for Hepatocellular Carcinoma After SVR. Authors' Reply. |
| Clin Gastroenterol Hepatol |
| Is enteroscopy alone adequate for assessment of mucosal healing in proximal ileum? |
| Moving Beyond Binaries: The Need to Include Both Sexual Orientation and Gender Identity in Disorders of Gut-Brain Interaction. |
| Re: Oral Contraceptives and Risk of GERD and Related Esophageal Outcomes - A Cautionary Tale of Hormonal Exposures in Large Database Networks. |
| Response to Letter to Editor. |
| Segmental Histologic Variability in MASLD/MASH: A Call to Quantify Reliability in Biopsy-Based Trial Endpoints. |
| Strategies to Reduce Hypoxemia During Gastrointestinal Endoscopy Using Optimized Low-Flow Oxygen Delivery. |
| Subcutaneous Infliximab and Assumptions of Response in Ileal Crohn's Disease: Does Route of Administration Matter? |
| Gastroenterology |
| Comments on "Can Colonoscopy Still Be Promoted as the Best Choice for Colorectal Cancer Screening?" |
| Gut |
| Methodological and reporting considerations for self-reported NCGWS prevalence. |
| Optimising mono-antibiotic eradication regimen by potent acid inhibitor and bismuth: a potential solution to rising clarithromycin resistance in <i>Helicobacter pylori</i>. |
| Rifaximin in symptomatic uncomplicated diverticular disease: a stewardship perspective following the Fiesole Consensus. |