111 articles - From Friday Feb 27 2026 to Friday Mar 06 2026
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Am J Gastroenterol |
|---|
| ACG Clinical Guideline: Hepatic Encephalopathy.
The Grading of Recommendations, Assessment, Development, and Evaluation process was used to assess the quality of evidence for each statement. Key concepts are also provided for statements to which the Grading of Recommendations, Assessment, Development, and Evaluation process has not been applied. |
| Gastrointest Endosc |
| A path forward: underrepresented in medicine-gastroenterology. |
| A path forward: women in gastroenterology. |
| Endoscopic closure devices (with videos). |
| Gut |
| Colorectal cancer in metabolic dysfunction-associated steatotic liver disease: an international Delphi consensus statement.
The expert panel emphasises the need for greater clinical vigilance for CRC among individuals with MASLD. This consensus supports a paradigm shift towards earlier, risk-adapted screening and integrated metabolic management to reduce the burden of CRC in the MASLD population. |
| Consensus guidance of immune checkpoint inhibitors in locally advanced rectal cancer.
Moreover, we refined the management process for the safety of perioperative immunotherapy. This document aims to provide a reference for surgeons; internal medicine, radiation therapy, pathology and imaging physicians; patients and nursing staff involved in the treatment of LARC, as well as health policy makers. |
meta-analyses and systematic reviews
| Am J Gastroenterol |
|---|
| Global Prevalence of Adherence to Gluten-Free Diet in Patients with Celiac Disease: A Systematic Review and Meta-analysis.
One in three patients with CeD is unable to maintain a good adherence to GFD. There is need to develop strategies to improve the adherence to GFD. |
| Endosc Int Open |
| Efficacy and acceptability of bowel preparation strategies for inflammatory bowel disease colonoscopy: Systematic review and meta-analysis.
High-certainty evidence supports low-volume PEG as comparably successful to high-volume PEG, with higher acceptability. Moderate-certainty evidence indicates similar success between non-PEG and PEG-based preps. Both low-volume PEG and non-PEG-based preps are supported for use in IBD, broadening options beyond current ESGE guidelines. |
| Endoscopy |
| Prophylactic clipping after colorectal endoscopic submucosal dissection in randomized controlled trials: a systematic review and meta-analysis.
Subgroup analyses by lesion size (>30 mm vs <30 mm) and location (proximal vs distal colon) were not significant. A 74% decrease in the risk of clinically significant delayed bleeding is achieved by prophylactic clipping after colorectal ESD, supporting its adoption in routine practice. |
| Gastrointest Endosc |
| Comparative Efficacy and Safety of Treatments for Malignant Gastric Outlet Obstruction: A Systematic Review and Network Meta-analysis.
EUS-GJ appears as the best treatment for malignant GOO. ES represents a valuable, widely available and less expensive alternative but with significantly higher need for reintervention. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
|---|
| Effects of a Personalised FODMAP Diet Versus the National Institute for Health and Care Excellence (NICE) Dietary Advice on Symptom Control in Patients With Irritable Bowel Syndrome: Randomised Clinical Trial.
An individualised, less restrictive personalised FODMAP diet yields symptom improvement comparable to NICE dietary advice while preserving nutritional adequacy. Personalised dietary strategies may enhance feasibility and long-term adherence in IBS management. |
| Fistula Calprotectin as a Biomarker of Local Inflammation and Treatment Response in Perianal Fistulizing Crohn's Disease.
FiCP represents a minimally invasive, tract-specific biomarker that mirrors local inflammatory activity and dynamically tracks treatment response in pfCD. Multicenter validation is warranted to define its clinical utility. |
| Am J Gastroenterol |
| Impact of Alkaline Phosphatase Normalization on Complication-Free Survival in Primary Biliary Cholangitis.
Achieving normal ALP and TB ≤0.6xULN is associated with significantly improved complication-free survival, particularly in high-risk patients. These findings highlight the potential of biochemical thresholds as a meaningful therapeutic goal in PBC management. |
| Patient Perspectives on Artificial Intelligence in Gastroenterology: A Multicenter Survey of Knowledge, Concerns, and Beliefs.
Patients in GI settings generally support AI as an assistive tool but prioritize physician oversight and transparency. Addressing knowledge gaps and demographic disparities is essential for equitable AI adoption in clinical GI. |
| Phenotypic presentation of pediatric inflammatory bowel disease through 4 decades: The Pediatric NorDIBD cohort.
The newly established unselected population-based pNorDIBD cohort shows an increase in both incidence and extensiveness of newly diagnosed pediatric IBD over the last 4 decades and provides a foundation for future research into the long-term outcomes of pediatric IBD. |
| The Costs of Inflammatory Bowel Disease and the Financial Impact of Insurance Delays.
Furthermore, PA denials often lead to the use of non-preferred agents lacking evidence of clinical benefit. This review will attempt to summarize the costs related to IBD, assess how delays related to the PA process and administrative processes contribute to both direct and indirect cost burdens, and identify strategies that can potentially reduce overall costs in both pediatric and adult IBD care. |
| Clin Gastroenterol Hepatol |
| EARLY INTERVENTION PREVENTS DISEASE PROGRESSION IN ULCERATIVE COLITIS - A MULTICENTER RETROSPECTIVE STUDY.
Starting BT early in the disease course may reduce the long-term risk of disease progression, reshaping the window of opportunity in UC. |
| Long-term Safety of Upadacitinib in Patients with Inflammatory Bowel Disease: Integrated Analysis of Phase 2/3 Studies.
Long-term, UPA was generally well tolerated. This integrated analysis supports the favorable safety profile of UPA and treatment decisions for patients with IBD. |
| Endosc Int Open |
| A novel polysaccharide hemostatic agent in prevention of post-procedural bleeding following large colonic polyp resection.
Use of a novel resorbable plant-based hemostatic powder could be a beneficial method for reducing delayed bleeding complications, particularly in high-risk groups characterized by specific lesions and patient factors. |
| Adenoma detection rates and complications of colonoscopy in patients aged 75 to 79 vs 70 to 74 years: Propensity score-matching study.
Colonoscopies for patients aged 75 to 79 are safe and effective in Japan. |
| Effect of a self-assembling peptide hydrogel on delayed bleeding following endoscopic sphincterotomy: Prospective pilot cohort study.
SAPH is a simple, effective, and safe hemostatic option for treating EST-related hemorrhage and may be a promising first-line approach. This pilot study did not demonstrate a significant reduction in delayed bleeding, but absence of delayed bleeding in the SAPH group is noteworthy and suggests a potential preventive benefit. Thus, larger randomized controlled trials are warranted to validate these preliminary findings. |
| Effect of virtual reality distraction on anxiety, pain and discomfort during unsedated gastroscopy: Randomized controlled trial.
VR distraction did not objectively reduce patient anxiety, pain, or discomfort before, during, or after the procedure. Moreover, willingness to undergo the same procedure without sedation was the same for the VR and control groups. Future research is needed to explore whether selected groups of patients may benefit from VR distraction. |
| Efficacy of chymotrypsin irrigation for endoscopically non-accessible walled-off necrosis in necrotizing pancreatitis.
Chymotrypsin irrigation effectively liquefies fibrotic necrotic tissue and promotes WON clearance via PCD, representing a promising adjunctive therapy for managing endoscopically non accessible WON. |
| Endoscopic ultrasonography-guided gastroenterostomy for malignant gastric outlet obstruction: Comparison between gastric and duodenal obstruction.
In this study, EUS-GE in patients with a gastric obstruction had comparable technical and clinical efficacy and a similar safety profile to EUS-GE for duodenal obstruction. However, gastric obstruction was associated with recurrent symptoms of obstruction unrelated to LAMS dysfunction. |
| Groove area involvement predicts post-ERCP pancreatitis after 8-mm fully-covered metal stent placement in resectable pancreatic cancer.
Groove-area tumor extension is an independent imaging-detectable PEP risk factor. Even after baseline difference adjustment, 8-mm FCSEMS placement was associated with a higher pancreatitis risk than PS placement. Pre-procedural groove involvement identification may guide stent selection and support selective prophylactic pancreatic stenting. However, further confirmation through larger prospective studies is required. |
| Long-term outcomes of surveillance or endoscopic therapy for low-grade dysplastic Barrett's according to a selective management algorithm.
This selective management algorithm for LGD is safe. Surveillance is appropriate in low-risk LGD patients. Patients with high-risk features who are surveilled and/or have reflux esophagitis may have an increased progression risk and should undergo EET with optimized acid suppression therapy. |
| Management of multicausal iatrogenic bile duct injuries with biliary fistula: Twenty-year experience in a tertiary center.
ERCP remains the best and least invasive treatment for hilar injuries, as evidenced by a high success rate. Management of NON-CCT-BDIs should be modeled after that of CCT-BDIs. Owing to the need for a combination of treatments, complex hilar injuries must be managed in expert centers. |
| Novel "rendez-vous" technique for persistent gastrocutaneous fistula closure.
The novel "rendezvous" technique has showed success in closure of persistent GC fistulas in comorbid patients with long-term PEG use. It is a less-invasive alternative to traditional surgery and produces greater closure rates than endoscopic clipping alone. |
| Partially covered or uncovered metal stent efficacy in malignant unresectable distal biliary obstruction (METARSI): Randomized multicenter trial.
PC-SEMS and U-SEMS in unresectable DBS showed comparable patency, survival, and stent dysfunction rates, with tumor ingrowth rarely observed and a trend toward more procedure-related complications in PC-SEMS. In this group with limited survival, there was no observed patency advantage with PC-SEMS. Potential benefit of PC-SEMS in populations with longer prognosis warrants further study. |
| Post-sleeve gastrectomy weight loss: Role of botulinum toxin and semaglutide injections.
Endoscopic botulinum toxin injection can be a safe and effective treatment for weight regain after LSG. |
| Preset pursestring procedure: Innovative auxiliary method of endoscopic full-thickness resection in small gastric stromal tumors.
PPP optimizes EFR closure, reduces inflammatory and abdominal complications, and improves postoperative recovery for small gastric stromal tumors. |
| Second lesions located within the same belt-like region along the stomach's short axis as primary lesions: Boundary equal lesion trends.
Synchronous multiple gastric neoplasms tend to have similar endoscopic and histopathologic features and often occur within the same belt-like region along the short axis of the stomach. This pattern was named boundary equal lesions trends (BELT). When detecting one lesion, considering BELT is essential. |
| Three-dimensional ERCP with cone-beam computed tomography: Novel approach to managing complex biliary strictures.
ERCP with CBCT is technically feasible with high selective cannulation rates in complex biliary strictures. Although the technique requires additional radiation exposure, it may provide value in cases with difficult selective cannulation and surgical mapping for malignancies. Further studies are needed to define optimal patient selection and evaluate long-term outcomes. |
| Treatment of benign biliary strictures with expandable biodegradable stents: Safety and efficacy in a single center.
Use of bioresorbable UNITY-B stents appears feasible and safe for selected benign biliary strictures, including in intrahepatic locations. Further studies are needed to confirm these preliminary findings. |
| Endoscopy |
| Evaluating the cost-effectiveness of artificial intelligence in Barrett's surveillance.
Additionally, AI reduced missed HGD/T1 incidence by 37 and 45 cases per 1000 people (relative reductions of 72.9% and 72.2%) for 3- and 5-yearly surveillance, respectively. AI-assisted endoscopic surveillance in BE was a cost-effective strategy in the Australian health care setting, reducing the cumulative incidence of advanced EAC and missed HGD/T1 lesions. |
| Gastric fundal mucosal ablation followed by endoscopic sleeve gastroplasty in adults with obesity: a first-in-human two-phase pilot clinical trial.
Sequential GFMA-ESG is safe and induces substantial weight loss, reduced MTV of ingested nutrients, and improved behavioral measures. This combination approach builds on prior traditional ESG and GFMA-only results and may represent a promising advancement of endoscopic therapeutic options for weight loss. |
| Gastroenterology |
| Acinar Metaplastic Cells Generate Semi-Homogeneous Niches and Interact With Immune Cells.
Our findings suggest that metaplastic cells can program immune cells in a specific manner at an early stage of cancer initiation to support an immunosuppressive microenvironment within defined niches. |
| Activation of the Integrin αV-YAP-CTGF Axis in Liver Sinusoidal Endothelial Cells Promotes Liver Fibrogenesis, Leading to Portal Hypertension and Liver Carcinogenesis in Congestive Hepatopathy.
CTGF induction in LSECs may play an upstream role in the fibrogenesis of CH. The integrin αV-YAP-CTGF axis in LSECs could be a potential therapeutic target for CH. |
| From Gut Feeling to Gray Matter: Mapping Defecation Urgency in Irritable Bowel Syndrome.
Urgency in IBS reflects a multidimensional phenomenon involving sensory and emotional aspects of gastrointestinal burden. Structural brain differences suggest divergent neural substrates underscoring the importance of distinguishing between experimentally induced and real-life urgency. |
| Targeting APE1-Redox Function Reverses SOX9-mediated Chemoresistance in Esophageal Adenocarcinoma.
Activation of SOX9 through the APE1-redox function is a key driver of EAC chemoresistance. Targeting APE1's redox activity offers a promising therapeutic strategy to overcome resistance by inhibiting the otherwise "undruggable" SOX9 transcription network. |
| The effect of dose-intensification after secondary loss of response to ustekinumab in Crohn's disease: Results of the REScUE study.
In patients with CD and secondary loss of response to ustekinumab, dose-intensification with a single intravenous administration and followed by 4 weekly subcutaneous dosing of ustekinumab was not more effective than one intravenous administration followed by 8 weekly SC dosing of ustekinumab. number NCT04245215. |
| Uncovering the dynamics of mucosa-associated microbiota in post-operative recurrence of Crohn's disease.
Altogether, these results provide further understanding of the effects of ileal resection patients with CD and show that disease recurrence is a dynamic process characterized by several waves of changes in the microbiota composition. |
| Gut |
| Bacterial genomic structural variations in children with autism serve as diagnostic biomarkers.
Our findings suggest the significant role of bacterial genomic SVs in ASD and highlight their potential as diagnostic biomarkers. |
| Impairment of Rab7-dependent STING degradation hampers HBV replication but accelerates disease progression in chronic hepatitis B comorbid with MASLD.
In CHB-MASLD comorbidity, impaired Rab7 function leads to aberrant STING accumulation in macrophages, suppressing HBV replication but paradoxically accelerating liver disease progression. Targeting Rab7 to degrade excessive STING represents a novel therapeutic strategy. |
| Hepatology |
| Low-dose chemotherapy remodels hepatic immune landscape and potentiates anti-tumor response to immune checkpoint blockade in cholangiocarcinoma.
This study highlights that LDGC remodels the immunosuppressive microenvironment and potentiates anti-PD-L1 therapy, providing a rational regimen for ICC. |
| The role of OSM/OSMRβ axis in shaping the tumor microenvironment favouring MASLD-Related HCC immune evasion.
Our findings provide compelling evidence for an autocrine role of OSM/OSMRβ axis in promoting CCL15 production by tumor cells which, in turn, stimulates an immunosuppressive TIME in MASH-HCCs, suggesting OSM as a potential therapeutic target for HCC treatment. |
| J Hepatol |
| Asynchronous Transitions from High-Risk Hepatoblastoma to Carcinoma.
Multi-omics profiling of HBCs revealed key findings about their biology and composition, demonstrating that they originate from HB precursors at early hepatic stem cell development stages and that their differentiation arrest depends on sustained aberrant WNT-signaling activity. |
| Efficacy of liver transplantation after response to atezolizumab-bevacizumab downstaging of intermediate and advanced hepatocellular carcinoma (ImmunoXXL).
LT after Atezo-Bev is characterized by competitive RFS estimates in intermediate and advanced HCC presenting beyond transplant indications. Acute rejection seems increased but remains clinically manageable. LT should be considered after HCC response to immunotherapy. Registration number NCT05879328. |
| Genetic evidence that FGF21 signaling reduces problematic alcohol use and alcohol-related liver disease.
Human genetic evidence indicates that FGF21 analogs mitigate hazardous drinking and ARLD via both behavioral and metabolic pathways, distinguishing them from other MASLD targets highlighting their potential for precision treatment of alcohol-related disorders. Impact and implications This study leverages human genetic evidence to validate FGF21-a liver-derived hormone currently in clinical trials for fatty liver disease-as a dual-action therapeutic that both curbs harmful drinking behaviors and protects against alcohol-related liver injury, addressing a critical therapeutic gap with limited existing pharmacotherapies. The results are important to clinicians and researchers seeking precision-medicine strategies for alcohol use disorder (AUD) and liver disease, as well as to patients who currently face limited treatment options. By pinpointing FGF21's behavioral and metabolic pathways and demonstrating a favorable safety profile, our findings support the repurposing of FGF21 analogs in clinical trials of AUD and alcohol-related liver disease and suggest that genetic stratification could optimize patient selection for therapy. While these conclusions rely on European-ancestry genetic data and MR assumptions, they help inform future clinical studies, biomarker development, and policy efforts aimed at expanding treatment options for alcohol-related conditions. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Gastroenterology |
|---|
| Our New President-Byron L. Cryer, MD, AGAF. |
| Gastrointest Endosc |
| A note from the Editor-in-Chief. |
| Anorectal dysfunction after endoscopic submucosal dissection for rectal lesions. |
| Clip smarter: patient selection for cost-effective prophylactic clip placement after polyp resection. |
| Endoscopic tunneled stricturotomy: an emerging minimally invasive solution for sleeve gastrectomy stenosis. |
| Fecal immunochemical test strategies: Is quantitative testing the only way forward in colorectal cancer screening? |
| From drainage to hemostasis: using self-assembling peptide gel for treatment of hemorrhage after pancreatic fluid collection drainage and necrosectomy. |
| Innovations in safety and expanding applications of AXIOS stent-delivery systems. |
| Is a pound of prevention worth an ounce of cure? |
| Is this the time to rethink the management options for biliary drainage in patients with malignant hilar biliary obstruction? |
| Lumen-apposing metal stent-assisted permanent endoscopic anastomosis: A new frontier? |
| Moving the needle on colorectal endoscopic submucosal dissection in the West. |
| Radiation matters: evaluating radiation dosage as a predictor of argon plasma coagulation outcome in radiation-associated vascular ectasias. |
| Refining endoscopic diagnosis in ulcerative colitis: the emerging role of lesion-border distinctness combined with pit pattern analysis. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| A Continuous Metallic Stream: Endoscopic Salvage of Migrated Hepatic Artery Coils. |
| Abdominal wall tumor seeding of Oral cavity squamous cell carcinoma. |
| Blue beads in the stomach and duodenum. |
| Calendar of Courses, Symposiums and Conferences. |
| Diarrhea-Associated Hypovolemic Shock due to Cronkhite-Canada Syndrome. |
| Management of a Giant, Bleeding Gastric Stromal Tumor: Endoscopic Ultrasound Guided Sclerotherapy with Lauromacrogol. |
| Response to Liao and Lai. |
| Endoscopy |
| An improved handmade snare-assisted method to optimize endoscopic tip angulation. |
| An ultra-early biliary occlusion caused by a blood clot impaction inside a multi-hole covered self-expandable metal stent. |
| Application of the novel peroral choledochoscope in hepatolithiasis after liver transplantation. |
| Autoimmune gastritis masquerading as subepithelial squamous infiltration: a case report. |
| Biliary network linkage using a side-hole-modified metal stent for concurrent endoscopic ultrasound-guided hepaticoduodenostomy. |
| Breaking through stent overgrowth: stepwise endoscopic removal using electrosurgical techniques. |
| Endoscopic ultrasound guided vascular intervention with digital subtraction angiography for isolated gastric varices: report of a video case. |
| Endoscopic ultrasound-guided creation of a drainage route combined with third-space endoscopy for esophageal intramural abscess debridement. |
| Endoscopic ultrasound-guided gallbladder drainage and electrohydraulic lithotripsy for the treatment of gallbladder neck stones. |
| Endoscopic ultrasound-guided glue embolization to prevent hemorrhage after accidental tract formation to the portal venous system during hepaticogastrostomy. |
| First successful percutaneous transhepatic cholangioscopic recanalization of post-hepatectomy biliary atresia with concurrent bile leak. |
| Hemostasis using traction clip closure and self-assembling peptide gel for gastric endoscopic submucosal dissection ulcer. |
| Malignant hilar biliary obstruction with active biliary bleeding: fully covered multi-hole metal stent deployed above papilla. |
| New bile duct cannulation technique using a fine-needle aspiration needle to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis. |
| Non-dilation endoscopic ultrasound-guided hepaticoduodenostomy and hepaticogastrostomy using a 7-Fr delivery system. |
| Novel bidirectional traction technique for tension-regulated large defect closure: a case report. |
| Preoperative bilateral drainage for perihilar cholangiocarcinoma via endoscopic ultrasound-guided hepaticogastrostomy using a novel side-hole plastic stent. |
| Robotic-assisted esophageal endoscopic submucosal dissection in a compact and extensive early Barrett's cancer lesion. |
| Stepwise endoscopic management of diospyrobezoar-induced small bowel obstruction using long-cap-assisted suction and balloon catheter. |
| Transesophageal endoscopic ultrasound-guided aspiration of the left atrium for diagnosis of T-cell lymphoblastic leukemia/lymphoma: a case report. |
| Gastroenterology |
| Advances in Immunotherapy for DNA Mismatch Repair-Deficient Colon and Rectal Cancers. |
| ERCP with Minor Papillotomy for Treatment of Recurrent Acute Pancreatitis in Patients with Pancreas Divisum. |
| Risk of Stomach Cancer with Long-term Use of Proton Pump Inhibitors. |
| Gut |
| Are the drugs already on the shelf? Repurposing therapy for pancreatitis. |
| Zinc-dependent post-transcriptional control of hepatocyte fate in and regeneration of alcohol-associated liver disease. |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
|---|
| Letter: Unlocking the Full Potential of Dietary Therapy in IBD-The Case for Universal Eating Disorder Screening. |
| Clin Gastroenterol Hepatol |
| Beyond the Plate: A Critical Appraisal of the Mediterranean Diet's Promise for IBS and Anxiety. |
| Reply: Toward More Equitable Liver Allocation: Optimizing the GEMA-AI Model for the Chinese Context. |
| Endosc Int Open |
| Is endoscopic submucosal dissection a first-line treatment for anal squamous cell carcinoma? |
| Size, morphology, site, and access scoring variability as a barrier to standardization and automation. |
| Gastroenterology |
| "Margin for Error"? Reassessing Non-Inferiority in the DSETAMIS Trial. |
| Endoscopic Submucosal Dissection (ESD) vs TransAnal Minimally Invasive Surgery (TAMIS) is not ESD vs Transanal Endoscopic Microsurgery (TEM). |
| Gastrointest Endosc |
| Gastroesophageal junction mucosal thickness, radiofrequency ablation depth limitation, and endoscopic mucosal resection + radiofrequency ablation combination: insights into Barrett's esophagus recurrence mechanism and clinical strategy. |
| Generalizability and implementation considerations for histopathologic evaluation of endoscopic ultrasound-guided fine-needle biopsy in solid pancreatic lesions. |
| Rethinking the balance between clearance and sphincter preservation in large common bile duct stones. |
| Gut |
| Absolute risk stratification of HCC after HCV cure in MASLD: do advanced steatosis and dysglycaemia add beyond liver stiffness? |
| Limitations of <i>Helicobacter pylori</i> single-method testing: evidence from a cohort study. |
| Screening for preclinical Crohn's disease based on capsule endoscopy is not yet ready. |
| Time-varying dynamics of hepatic steatosis and cardiometabolic risk: implications for posthepatitis C cure HCC risk. |
| J Hepatol |
| Comment on "Serum procalcitonin: A novel tumor biomarker for … fibrolamellar hepatocellular carcinoma" by Nault et.al. |
| Responses to "Letters to the Editors" by Luo et al. and Chen et al. |